HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Eflornithine
EFLORNITINE · L-Eflornithine · DIFLUOROMETHYLORNITHINE · DFMO · L-DFMO · L-RMI71782 · H-DL-(F2ME)ORN-OH · L-α-difluoromethylornithine
Identifiers & Physical Properties
| CAS No. | 66640-93-5 |
|---|---|
| Molecular formula | C6H12F2N2O2 |
| Average molar mass | 182.17 g/mol |
| Monoisotopic mass | 182.08668406 g/mol |
| SMILES | NCCC[C@](N)(C(=O)O)C(F)F |
| InChIKey | VLCYCQAOQCDTCN-ZCFIWIBFSA-N |
| PubChem CID | 6992039 |
| ChEMBL | CHEMBL222838 |
| DTXSID | DTXSID00880061 |
Chemical & Physical Properties
| XLogP | -2.9 |
|---|---|
| Topological polar surface area | 89.3 |
| Hydrogen bond donors | 3 |
| Hydrogen bond acceptors | 6 |
| Rotatable bonds | 5 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 166 |
| Drugs | Pharmaceuticals -> Listed in ZINC15 |
| Boiling point | 347.0±42.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| Storage conditions | Store at -20°C |
| Solubility | Soluble in DMSO |
| pKa (acidity coefficient) | 1.22±0.44(Predicted) |
| NCI Dictionary of Cancer Terms | difluoromethylornithine |
| FDA UNII | C780YUS9YI |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P280-P305+P351+P338 |
Safety & Regulations
| Signal word | Warning |
|---|---|
| GHS pictogram | GHS07 |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P280-P305+P351+P338 |
Applications & Uses
Uses
L-Eflornithine (L-DFMO) is an enantiomer of Eflornithine. L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1[1].