Basic information
- CAS
229305-39-9- Standard SMILES
N[C@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)O- InChIKey
CATMPQFFVNKDEY-YPMHNXCESA-N- Molecular formula
- C16H19N3O5
- Average molar mass
- 333.34 g/mol
- Monoisotopic mass
- 333.13247072
Overview
Golotimod is a dipeptide.
Names & identifiers
- Preferred name
- Golotimod
- IUPAC
- (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
- English name
- H-D-GLU(TRP-OH)-OH
- Molecular formula
- C16H19N3O5
- Molecular weight
- 333.34
Names & synonyms
Golotimod229305-39-9SCV-07SCV07SCV 07(2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid637C487Y09DTXSID10177474D-GAMMA-GLUTAMYL-L-TRYPTOPHAN(2R)-2-Amino-5-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acidgolotimodumRefChem:782622
Show more names
GLU-TRPGAMMA-GLU-TRPUnii-637C487Y09H-g-D-Glu-Trp-OHH-GLU(TRP-OH)-OHH-GAMMA-GLU-TRP-OHH-GAMMA-D-GLU-TRP-OH
DTXCID3099965(2R)-2-amino-4-(((1S)-1-carboxy-2-(1H-indol-3-yl)ethyl)carbamoyl)butanoic acidH-D-Glu(Trp-OH)-OHgamma-D-Glu-L-trpgamma-D-Glutamyl-L-tryptophan(R)-2-Amino-5-(((S)-1-carboxy-2-(1H-indol-3-yl)ethyl)amino)-5-oxopentanoic acidGolotimod [USAN]Golotimod [USAN:INN]
Database identifiers
- CAS
229305-39-9- PubChem CID
- 6992140
- DTXSID
Properties
Computed structural properties
- XLogP
- -2.7
- Topological polar surface area
- 146 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 8
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 484
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Boiling point
- 737.3 · 737.3±60.0 °C(Predicted)
- Density
- 1.428 · 1.428±0.06 g/cm3(Predicted)
- storage temp.
- 20 °C · −20°C
- solubility
- Soluble in DMSO
- pka
- 2.22 · 2.22±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- FDA UNII
- 637 C487Y09 · 637C487Y09
- NCI Drug Dictionary
- golotimod
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
Chemistry & industry
Pharmacology
Pharmacodynamics
SCV-07 (g -D-glutamyl-L-tryptophan) is a novel synthetic dipeptide that acts broadly on the Toll-like receptor pathway. It has been shown to stimulate T-lymphocyte differentiation, macrocytic phagocytosis, and specific immune responses, and enhance IL-2 and INF-g production.
Mechanism of ActionSCV-07 (g -D-glutamyl-L-tryptophan) has broad effects on the Toll-like receptor (TLR) pathway.
Applications
UsesGolotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].
Suppliers57 total
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
郑州汇聚化工有限公司0371-53399770 18037166334 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
浙江珲达生物科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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