HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylsulfanyl)butanoic acid
FMOC-D-MET-OH · FMOC-D-MET · (((9H-Fluoren-9-yl)methoxy)carbonyl)-D-methionine · Fmoc-Met-OH · FMOC-D-METHIONINE · Fmoc-D-Met-OH 98% · D-FMOC-methionine · N-FMOC-D-METHIONINE
Identifiers & Physical Properties
| CAS No. | 112883-40-6 |
|---|---|
| Molecular formula | C20H21NO4S |
| Average molar mass | 371.5 g/mol |
| Monoisotopic mass | 371.11912915 g/mol |
| SMILES | CSCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O |
| InChIKey | BUBGAUHBELNDEW-GOSISDBHSA-N |
| PubChem CID | 6992521 |
| EC No. | 958-460-1 |
| DTXSID | DTXSID90426316 |
Chemical & Physical Properties
| XLogP | 3.7 |
|---|---|
| Topological polar surface area | 101 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 5 |
| Rotatable bonds | 8 |
| Heavy atoms | 26 |
| Formal charge | 0 |
| Complexity | 478 |
| Melting point | 132 °C |
| Boiling point | 614.6±55.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| Refractive index | 30 ° (C=1, DMF) |
| Storage conditions | 2-8°C |
| Solubility | Chloroform (Slightly), DMF (Slightly), Methanol (Slightly) |
| Physical state | Solid |
| pKa (acidity coefficient) | 3.72±0.10(Predicted) |
| Color | White to Off-White |
| BRN | 5384578 |
| Major applications | peptide synthesis |
| InChI | 1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m1/s1 |
| InChIKey | BUBGAUHBELNDEW-GOSISDBHSA-N |
| SMILES | CSCC[C@@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O |
| CAS DataBase Reference | 112883-40-6(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| Safety statements (S) | 22-24/25 |
| Water hazard class (WGK) | 3 |
| Customs code | 29309090 |
| Storage class | 11 - Combustible Solids |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Water hazard class (WGK) | 3 |
| Customs code | 29309090 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Safety statements (S) | 22-24/25 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
Applications & Uses
Uses
N-Fmoc-D-methionine is an N-Fmoc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).