1,3,2-Dioxaphospholane, 2-chloro-

HCID 69973

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Basic information

CAS: 822-39-9
Standard SMILES: ClP1OCCO1
InChIKey: OLSFRDLMFAOSIA-UHFFFAOYSA-N
Molecular formula: C2H4ClO2P
Average molar mass: 126.48 g/mol
Monoisotopic mass: 125.9637441

Names & identifiers

Preferred name: 1,3,2-Dioxaphospholane, 2-chloro-
IUPAC: 2-chloro-1,3,2-dioxaphospholane
English name: 2-Chloro-1,3,2-dioxaphospholane
Molecular formula: C2H4ClO2P
Molecular weight: 126.48

Names & synonyms

2-Chloro-1,3,2-dioxaphospholane822-39-91,3,2-Dioxaphospholane, 2-chloro-EINECS 212-499-4DTXSID4061173RefChem:72181DTXCID8048280212-499-4InChI=1/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2HEthylene chlorophosphiteMFCD00014511C2H4ClO2P

Show more names

AURORA KA-1222Ethyl chlorphosphiteEthylenechlorophosphite,97%EthylenephosphorochloriditeETHYLENE CYCL-CHLOROPHOSPHITE2-dioxaphospholane,2-chloro-3Ethylene glycol chlorophosphite

Ethylene cyclo-ChlorophosphiteSCHEMBL5849OLSFRDLMFAOSIA-UHFFFAOYSA-NAKOS0159127702-Chloro-1,3,2-dioxaphospholane, 97%SY048436DB-031353NS00038179

Database identifiers

CAS: 822-39-9
PubChem CID: 69973
DTXSID: DTXSID4061173
EC Number: 212-499-4
Nikkaji: J26.475J

Properties

Computed structural properties

XLogP: 0.6
Topological polar surface area: 18.5 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 6
Formal charge: 0
Complexity: 44.8

Experimental & physicochemical properties

SpringerMaterials PropertiesSchoenflies notation

Physicochemical properties

Melting point: -28 °C · -28°C(lit.)
Boiling point: 62 °C/20 · 62 °C/20 mmHg (lit.)
Density: 1.422 g/mL · 1.422 g/mL at 25 °C (lit.)
refractive index: 20 · n20/D 1.489(lit.)
Flash point: 158 °F · 158 °F
storage temp.: 2 · 2-8°C
solubility: Chloroform (Slightly)
form: clear liquid
color: Colorless to Light yellow
Sensitive: Moisture Sensitive
BRN: 506179 · 506179
Stability: Extremely Moisture Sensitive
InChI: 1S/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2
InChIKey: OLSFRDLMFAOSIA-UHFFFAOYSA-N
SMILES: ClP1OCCO1
CAS DataBase Reference: 822 · 822-39-9(CAS DataBase Reference)
NIST Chemistry Reference: Ethylene chlorophosphite(822-39-9)
EPA Substance Registry System: 1 · 1,3,2-Dioxaphospholane, 2-chloro- (822-39-9)
UNSPSC Code: 12352005 · 12352005
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS07
Signal word: Danger
Hazard statements: 314 · H314-H335
Precautionary statements: 261 · P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
target organs: Respiratory system
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C
Risk Statements: 14 · 14-34-37
Safety Statements: 26 · 26-36/37/39-45-8-25
RIDADR: 3264 · UN 3264 8/PG 2
WGK Germany: 3 · 3
F: 1 · 1-10
Hazard Note: Highly reactive cyclic phosphitylating reagent which
TSCA: TSCA listed
HS Code: 2934.99 · 2934.99.9001
HazardClass: 8 · 8
PackingGroup: II
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 BSTOT · Skin Corr. 1BSTOT SE 3

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

GHS classification

GHS Classification · 4 items

Danger

H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Corr. 1B (100%)

Safety data

F: 1-10
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 3
tsca: TSCA listed
ridadr: UN 3264 8/PG 2
hs_code: 2934.99.9001
risk_code: 14-34-37
Signal word: Danger
Symbol(GHS): GHS05,GHS07
hazard_code: C
hazard_note: Highly reactive cyclic phosphitylating reagent which
safety_code: 26-36/37/39-45-8-25
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: II
target organs: Respiratory system
Hazard statements: H314-H335
Hazard Classifications: Skin Corr. 1BSTOT SE 3
Precautionary statements: P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Chemistry & industry

Uses & manufacturing

General Manufacturing Information1,3,2-Dioxaphospholane, 2-chloro-: ACTIVE

Applications

UsesHighly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

UsesEthylene chlorophosphite acts as a phosphitylating agent involved in the preparation of phosphocholine and spirophosphoranes. For example, it is used in the phosphorylation of p-tert-butyl(thia)calixarenes.

Upstream & downstream products

Downstream products

2-Chloro-1,3,2-dioxaphospholane-2-oxide

Suppliers76 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

上海摩睿化学科技有限公司13382110328 15255501563 · [email protected]

Related reactions

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Compound notes

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