Stf-62247
Basic information
- CAS
315702-99-9- Standard SMILES
Cc1cccc(Nc2nc(-c3ccncc3)cs2)c1- InChIKey
KATNUHQNJGNLPW-UHFFFAOYSA-N- Molecular formula
- C15H13N3S
- Average molar mass
- 267.4 g/mol
- Monoisotopic mass
- 267.0830186
Overview
N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.
Names & identifiers
- Preferred name
- Stf-62247
- IUPAC
- N-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine
- English name
- STF-62247
- Molecular formula
- C15H13N3S
- Molecular weight
- 267.35
Names & synonyms
STF-62247315702-99-9STF 62247DTXSID90351598STF62247RefChem:382027DTXCID70302664Autophagy Inducer, STF-622474-(pyridin-4-yl)-N-(m-tolyl)thiazol-2-amineN-(3-methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amineMFCD01121974N-(3-methylphenyl)-4-(pyridin-4-yl)-1,3-thiazol-2-amine
Show more names
ERRORCS-2363UV0364770STF-62247 (STF62247STF-62247 USP/EP/BPSTF-62247, 10 mM in DMSO
4-(pyridin-4-yl)-N-m-tolylthiazol-2-amineN-(3-Methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amineSMR000279642SR-01000477178N-(m-tolyl)-4-(4-pyridyl)thiazol-2-amineOprea1_055220Oprea1_578909MLS000765936
Database identifiers
- CAS
315702-99-9- PubChem CID
- 704473
- DTXSID
DTXSID90351598- ChEMBL
CHEMBL565269- ChEBI
CHEBI:125656- EC Number
- 631-141-1
- Nikkaji
- J3.666.560B
Properties
Computed structural properties
- XLogP
- 3.8
- Topological polar surface area
- 66.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 281
Physicochemical properties
- Melting point
- 158 · 158-160℃
- Density
- 1.255 · 1.255
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 26 mg/mL · DMSO: soluble26mg/mL
- form
- solid
- color
- Off-white
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
- InChIKey
- KATNUHQNJGNLPW-UHFFFAOYSA-N
- SMILES
- Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 413 · H413
- Precautionary statements
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (95%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (95%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
- wgk
- 2
- risk_code
- 22-36
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 26-39
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H413
- Hazard Classifications
- Aquatic Chronic 4
- Precautionary statements
- P273-P501
Chemistry & industry
Applications
DescriptionSTF-62247 (315702-99-9) specifically induces autophagic cell death in VHL (von Hippel-Lindau)-deficient renal carcinoma cells both in vitro (IC50=625 nM) and in vivo. Renal cell carcinoma cell lines were radiosensitized by induction of autophagy following treatment with STF-62247. Cell permeable
UsesAutophagy Inducer, STF-62247 is selectively kills RCC cells that have lost VHL tumor suppressor activity.
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: N-(3-methylphenyl)-4-pyridin-4-yl-2-thiazolamine is a substituted aniline.
Suppliers
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Compound notes
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