2-Hydroxy-5-methylpyridine

HCID 70482CAS 1003-68-5
Substructure searchFind similar structures

Basic information

Standard SMILES
Cc1ccc(=O)[nH]c1
InChIKey
SOHMZGMHXUQHGE-UHFFFAOYSA-N
Molecular formula
C6H7NO
Average molar mass
109.13 g/mol
Monoisotopic mass
109.05276384

Overview

5-Methyl-2-pyridinol is a member of methylpyridines.

Names & identifiers

Preferred name
2-Hydroxy-5-methylpyridine
IUPAC
5-methyl-1H-pyridin-2-one
English name
2-Hydroxy-5-methylpyridine
Molecular formula
C6H7NO
Molecular weight
109.13

Names & synonyms

2-Hydroxy-5-methylpyridine1003-68-55-Methyl-2-pyridone5-Methyl-2(1H)-pyridinoneC173P2D70YDTXSID20143120RefChem:537051DTXCID3065611213-713-95-methylpyridin-2-ol91914-06-65-Methylpyridin-2(1H)-one
Show more names
AKOS BBS-00002970Hydroxy-5-Methylpyrid5-Methyl-2-oxopyridine2-Hydroxy-5-methyL6-HYDROXY-3-PICOLINE
5-methyl-1H-pyridin-2-one2-Hydroxy-5-picoline5-Methyl-2-pyridinol2-Pyridinol, 5-methyl-2(1H)-Pyridinone, 5-methyl-Pirfenidone EP Impurity B5-methyl-pyridin-2-ol5-methyl-2(1H)-pyridone

Database identifiers

CAS
1003-68-5、1192-99-0、91914-06-6
PubChem CID
70482
DTXSID
DTXSID20143120
ChEBI
CHEBI:194862
UNII
C173P2D70Y
EC Number
213-713-9、618-801-4
Nikkaji
J110.369E

Properties

Computed structural properties

XLogP
0.1
Topological polar surface area
29.1 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
1
Rotatable bonds
0
Heavy atoms
8

Physicochemical properties

Melting point
183 · 183-187 °C (lit.)
Boiling point
304.2 · 304.2±15.0 °C(Predicted)
Density
1.053 · 1.053±0.06 g/cm3(Predicted)
storage temp.
Sealed in dry,Room Temperature
solubility
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form
Solid

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 8% (4 of 50) of reports.

Danger

H302 (80%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 50 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Hazard information

Regulatory InformationStatus: Active Update: 27-02-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/18172
Hazard Classes and Categories · 2 items

Acute Tox. 4 (80%)

Skin Irrit. 2 (100%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
hs_code
29333990
risk_code
22-37/38-41-36/37/39
Signal word
Danger
Symbol(GHS)
GHS05,GHS07

Chemistry & industry

Applications · 1 item

Uses2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. 2-hydroxy-5-methylpyridine and Iodobenzene were the impurities present in Pirfenidone (PFD) drug substance. PFD is a novel antifibrotic agent approved for mild to moderate Idiopathic pulmonary fibrosis (IPF) as orphan drug[1].

Upstream & downstream products

Suppliers50 total

上海美律医药科技有限公司+86-53530655; +8613916485955 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]
苏州启航生物科技有限公司18151111370 · [email protected]

Additional notes

DefinitionChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines.

Related reactions

32 records
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Linked notes

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