Mops

HCID 70807CAS 1132-61-2
Substructure searchFind similar structures

Basic information

Standard SMILES
O=S(=O)(O)CCCN1CCOCC1
InChIKey
DVLFYONBTKHTER-UHFFFAOYSA-N
Molecular formula
C7H15NO4S
Average molar mass
209.27 g/mol
Monoisotopic mass
209.07217913

Names & identifiers

Preferred name
Mops
IUPAC
3-morpholin-4-ylpropane-1-sulfonic acid
English name
MOPS
Molecular formula
C7H15NO4S
Molecular weight
209.26

Names & synonyms

MOPS1132-61-23-Morpholinopropanesulfonic acid4-Morpholinepropanesulfonic acid3-(N-Morpholino)propanesulfonic acidMorpholinopropane sulfonic acid3-morpholin-4-ylpropane-1-sulfonic acidMorpholinopropanesulfonic acidDTXSID4044371273BP63NV3DTXCID2024371CHEBI:44115
Show more names
MOPS FREE ACID4-propanesulfonyl morpholine3-Morpholinopropanesulfoinc Acid4-morpholinopropanesulphonic acid3-MORPHOLINOPROPANESULPHONIC ACID
RefChem:926116morpholine propanesulphonic acidCHEBI:39074214-478-53-Morpholinopropane-1-sulfonic acid3-(morpholin-4-yl)propane-1-sulfonic acid3[N-MORPHOLINO]PROPANE SULFONIC ACIDMFCD00006183

Database identifiers

CAS
1132-61-2
PubChem CID
70807
DTXSID
DTXSID4044371
ChEMBL
CHEMBL1234443
ChEBI
CHEBI:44115
UNII
273BP63NV3
EC Number
214-478-5
Nikkaji
J7.270B

Properties

Computed structural properties

XLogP
-3.1
Topological polar surface area
75.2 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
5
Rotatable bonds
4
Heavy atoms
13

Experimental & physicochemical properties

Physical DescriptionWhite solid; [Merck Index] White odorless powder; [Caledon Laboratories MSDS]
Collision Cross Section · 1 item

142.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；149.5 Ų [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；154.6 Ų [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；142.4 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]

Physicochemical properties

Melting point
277 · 277-282 °C
Density
1.3168 · 1.3168 (rough estimate)
bulk density
350 kg/m3 · 350kg/m3
vapor pressure
0 Pa · 0Pa at 25℃
refractive index
1.637 · 1.6370 (estimate)
Flash point
116 °C · 116 °C

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 45.9% (189 of 412) of reports.

Warning

H315 (53.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (53.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (52.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 412 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 189 of 412 reports by companies.；There are 16 notifications provided by 223 of 412 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: 4-Morpholinepropanesulfonic acid

Status: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270；Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115

MOPS: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Caledon Laboratories MSDS] See N-Ethylmorpholine.
Hazard Classes and CategoriesSkin Irrit. 2 (53.4%)；Eye Irrit. 2 (53.4%)；STOT SE 3 (52.7%)

Regulatory information

Regulatory Information · 3 items

Chemical: 4-Morpholinepropanesulfonic acid

Status: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270；Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115

MOPS: Does not have an individual approval but may be used under an appropriate group standard

Safety data

wgk
1
tsca
TSCA listed
rtecs
QE9104530
hs_code
29349990
risk_code
36/37/38
Signal word
Warning

Chemistry & industry

Uses & manufacturing

UsesUsed as a biological buffer; [Merck Index] Used as a laboratory reagent; [Caledon Laboratories MSDS]
General Manufacturing Information4-Morpholinepropanesulfonic acid: ACTIVE
Applications · 4 items

DescriptionMOPS (3-morpholinopropanesulfonic acid) is a buffer introduced by Good et al. in the 1960s. It is a structural analog to MES. Its chemical structure contains a morpholine ring. HEPES is a similar pH buffering compound that contains a piperazine ring. With a pKa of 7.20, MOPS is an excellent buffer for many biological systems at near-neutral pH.It is used as a synthetic buffering agent below pH 7.5.

UsesMOPS acts as a multi-purpose buffering agent used in various biological research.

UsesDue to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production, a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.

General Description3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.

Upstream & downstream products

Upstream raw materials

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
武汉德晟生化科技有限公司0711-3702650 18971041571 · [email protected]
Additional notes · 1 item

DefinitionChEBI: 3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 ℃. It is a member of morpholines, a MOPS and an organosulfonic acid. It is a conjugate acid of a 3-(N-morpholino)propanesulfonate. It is a tautomer of a 3-(N-morpholiniumyl)propanesulfonate.

Related reactions

33 records
New reaction record

Linked notes

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