Basic information
- CAS
78466-98-5- Standard SMILES
Cc1[nH]nc2c1N(c1ccccc1)C(=O)CC(=O)N2C- InChIKey
RHZDHINXKVZTEF-UHFFFAOYSA-N- Molecular formula
- C14H14N4O2
- Average molar mass
- 270.29 g/mol
- Monoisotopic mass
- 270.1116757
Overview
Razobazam is a small molecule drug. Razobazam has a monoisotopic molecular weight of 270.11 Da.
Names & identifiers
- Preferred name
- Hoe 175
- IUPAC
- 3,8-dimethyl-4-phenyl-2H-pyrazolo[3,4-b][1,4]diazepine-5,7-dione
- English name
- Razobazam
- Molecular formula
- C14H14N4O2
- Molecular weight
- 270.29
Names & synonyms
Hoe 175Hoe-175Pyrazolo(3,4-b)(1,4)diazepine-5,7(1H,6H)-dione, 4,8-dihydro-3,8-dimethyl-4-phenyl-RefChem:923020Razobazam78466-98-5Razobazam [INN]3,8-dimethyl-4-phenyl-2H-pyrazolo[3,4-b][1,4]diazepine-5,7-dioneLZ84VWN0U44,8-Dihydro-3,8-dimethyl-4-phenylpyrazolo(3,4-b)(1,4)diazepine-5,7(1H,6H)-dione3,8-dimethyl-4-phenyl-4,8-dihydropyrazolo[3,4-b][1,4]diazepine-5,7(1H,6H)-dioneRazobazamum [Latin]
Show more names
4,8-Dihydro-3,8-dimethyl-4-phenylpyrazolo[3,4-b][1,4]diazepine-5,7(1H,6H)-dionePyrazolo[3,4-b][1,4]diazepine-5,7(1H,4H)-dione, 6,8-dihydro-3,8-dimethyl-4-phenyl-
Razobazamum3,8-dimethyl-4-phenyl-5,6,7,8-tetrahydropyrazolo-(3,4-b)(1,5)-diazepine-1H,4H-5,7-dioneUNII-LZ84VWN0U4orb1701717SCHEMBL2110421SCHEMBL2110423CHEMBL2106934DTXSID20868482
Database identifiers
- CAS
78466-98-5
Properties
Computed structural properties
- XLogP
- 1.1
- Topological polar surface area
- 69.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 408
Physicochemical properties
- Boiling point
- 706.3 · 706.3±60.0 °C(Predicted)
- Density
- 1.343 · 1.343±0.06 g/cm3(Predicted)
- pka
- 9.08 · 9.08±0.20(Predicted)
- FDA UNII
- 84 VWN0U4 · LZ84VWN0U4
Chemistry & industry
Applications
UsesRazobazam (Hoe 175) is a benzodiazepine derivative with cognitive activity. Razobazam has been shown to improve learning performance in socially deprived rats. Razobazam increased avoidance scores by 18% after training. Razobazam caused significant changes in the optical density of certain areas of the rat brain, including a 22% decrease in the lateral habenula and a 25% increase in the ventral tegmental area. Razobazam also caused a 13% increase in optical density in the prefrontal cortex of rats[1].
Suppliers4 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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