Basic information
- CAS
78664-73-0- Standard SMILES
CC(C)C[C@H](NC(=O)[C@@H]1CCCC(=O)N1)C(=O)N1CCC[C@H]1C(N)=O- InChIKey
DPNGIIPSQYKWQA-AVGNSLFASA-N- Molecular formula
- C17H28N4O4
- Average molar mass
- 352.4 g/mol
- Monoisotopic mass
- 352.21105539
Overview
Posatirelin is an oligopeptide.
Names & identifiers
- Preferred name
- Posatirelin
- IUPAC
- (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]-6-oxopiperidine-2-carboxamide
- English name
- Posatirelin
- Molecular formula
- C17H28N4O4
- Molecular weight
- 352.43
Names & synonyms
Posatirelin78664-73-0PosatirelineRGH-2202PosatirelinaPosatirelinumpAad-Leu-Pro-NH278U6302ARLDTXSID301318172L-Prolinamide, N-((6-oxo-2-piperidinyl)carbonyl)-L-leucyl-, (S)-L-6-ketopiperidine-2-carbonyl-leucyl-proline amidepyro-2-aminoadipoyl-leucyl-prolinamide
Show more names
BRN6006446BRN 6006446BRN-6006446N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
RefChem:175327DTXCID601747960Posatirelin [INN](2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]-6-oxopiperidine-2-carboxamidePyladox(2S)-6-Oxo-2-piperidinecarbonyl-L-leucyl-L-prolinamidePosatireline [INN-French]Posatirelinum [INN-Latin]
Database identifiers
- CAS
78664-73-0
Properties
Computed structural properties
- XLogP
- -0.5
- Topological polar surface area
- 122 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 549
Physicochemical properties
- Melting point
- 214 · 214-216°
- alpha
- 25 · D25 -80.2° (c = 1 in acetic acid)
- Boiling point
- 739.6 · 739.6±60.0 °C(Predicted)
- Density
- 1.214 · 1.214±0.06 g/cm3(Predicted)
- pka
- 13.56 · 13.56±0.20(Predicted)
- FDA UNII
- 78 U6302ARL · 78U6302ARL
Chemistry & industry
Applications
DescriptionPosatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.
UsesPosatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.
Upstream & downstream products
Upstream raw materials
Suppliers6 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
江苏洪珉药业有限公司18221292452 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…