Etofenprox (HCID 71245)

Overview

Etofenprox is an aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol. It has a role as a pyrethroid ether insecticide. It is functionally related to a 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.

Names & identifiers

Preferred name: Etofenprox
IUPAC: 1-ethoxy-4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]benzene
English name: Etofenprox
Molecular formula: C25H28O3
Molecular weight: 376.49

Names & synonyms

Etofenprox80844-07-1Ethofenprox1-((2-(4-Ethoxyphenyl)-2-methylpropoxy)methyl)-3-phenoxybenzeneEthophenproxEtofenproxumDTXSID90326100LD7P9153CDTXCID7012610CHEBI:39348Benzene, 1-((2-(4-ethoxyphenyl)-2-methylpropoxy)methyl)-3-phenoxy-1-{[2-(4-ethoxyphenyl)-2-methylpropoxy]methyl}-3-phenoxybenzene

Show more names

PEPENUKILTREBONmti500VECTRONPUNKASOLenatop

2-(4-ethoxyphenyl)-2-methylpropyl-3-phenoxybenzyl etherRefChem:139268407-980-2Etofenprox [INN]1-ethoxy-4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]benzeneMFCD002102872-(4-Ethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether1705649-55-3

Database identifiers

CAS: 1705649-55-3、80844-07-1
PubChem CID: 71245
DTXSID: DTXSID9032610
ChEMBL: CHEMBL2105573
ChEBI: CHEBI:39348
UNII: 0LD7P9153C
EC Number: 109-904-0、407-980-2、617-179-1
Nikkaji: J33.917B

Properties

Computed structural properties

XLogP: 7
Topological polar surface area: 27.7 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 3
Rotatable bonds: 9
Heavy atoms: 28
Formal charge: 0
Complexity: 422

Experimental & physicochemical properties

Pesticides · 6 items

Agrochemicals -> Pesticide active substances

Active substance -> EU Pesticides database: Approved

Environmental transformation -> Pesticides (parent, predecessor)

Pesticide

Insecticides

Pesticide (Etofenprox) -> USDA PDB

LogP7.05

Endocrine DisruptorsPotential endocrine disrupting compound

Collision Cross Section · 3 items

191.0 Å² [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID9032610]

191.81 Å² [M+Na]+

189.38 Å² [M]+ [CCS Type: TW; Buffer gas: N2; Ionization: GC-APCI+]

Physicochemical properties

Melting point: 36.4 · 36.4-38.0°
Boiling point: 445.03 °C · 445.03°C (rough estimate)
Density: 1.1386 · 1.1386 (rough estimate)
vapor pressure: 32 · 32×10-3 Pa (100 °C)
refractive index: 20.2 · nD20.2 1.5732
storage temp.: Sealed in dry,Room Temperature
solubility: 100 mg/mL · DMSO: 100 mg/mL (265.61 mM)
form: Solid
Water Solubility: -1 · -1(25 °C)
color: Off-white to light yellow
Henry's Law Constant: 7.4 · 7.4×101 mol/(m3Pa) at 25℃, Maniere et al. (2011)
Stability: Stable. Incompatible with strong oxidizing agents.
Major Application: agricultureenvironmental
InChI: 1S/C25H28O3/c1-4-27-22-15-13-21(14-16-22)25(2,3)19-26-18-20-9-8-12-24(17-20)28-23-10-6-5-7-11-23/h5-17H,4,18-19H2,1-3H3
InChIKey: YREQHYQNNWYQCJ-UHFFFAOYSA-N
SMILES: CCOc1ccc(cc1)C(C)(C)COCc2cccc(Oc3ccccc3)c2
CAS DataBase Reference: 80844 · 80844-07-1(CAS DataBase Reference)
FDA UNII: 0 LD7P9153C · 0LD7P9153C
NIST Chemistry Reference: Etofenprox(80844-07-1)
EPA Substance Registry System: Etofenprox (80844-07-1)
UNSPSC Code: 41116107 · 41116107
NACRES: 24 · NA.24
Symbol(GHS): 9 · GHS09
Signal word: Warning
Hazard statements: 362 · H362-H410
Precautionary statements: 201 · P201-P260-P263-P273-P308+P313-P391
PPE: 95 · Eyeshields, Gloves, type N95 (US)
RIDADR: 3077 · UN 3077 9 / PGIII
WGK Germany: 2 · 2
RTECS: 670000 · DA0670000
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 1 Aquatic · Aquatic Acute 1Aquatic Chronic 1Lact.
Toxicity: 50 in · LD50 in rats, mice (mg/kg): >2880, >107200 orally; >2140, >2140 dermally
REACH Registrations: Inactive

Safety & regulation

GHS classification

GHS Classification · 6 items

Warning

H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

P203, P260, P263, P264, P270, P273, P318, P391, and P501 (click each P-code to see the statement)

Warning

H362 (96.7%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]

P203, P260, P263, P264, P270, P273, P318, P391, and P501 (click each P-code to see the statement)

Hazard information

Regulatory Information · 5 items

Commission Regulation (EC) No 1490/2002

Etofenprox is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)

2009/77/EC, Reg. (EU) 2021/1449, Reg. (EU) 2022/1480, Reg. (EU) 2023/2592, Reg. (EU) No 540/2011

Status: Cease Manufacture Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/4043

Etofenprox: HSNO Approval: HSR003567 Approved with controls

Hazard Classes and Categories · 6 items

Lact. (75%)

Lact. (96.7%)

Lact. (100%)

Reproductive toxicity - effects on or via lactation

Hazardous to the aquatic environment (Acute) - Category 1

Specific target organ toxicity - Single exposure - Category 1 (central nervous system), Category 3 (narcotic effects)

Toxicology

RAIS Toxicity Values · 2 items

0.0255

OPP

EPA Human Health Benchmarks for Pesticides · 5 items

Etofenprox

0.0255

151

General Population

Human Health Benchmarks for Pesticides - 2021 Update

Safety data

PPE: Eyeshields, Gloves, type N95 (US)
wgk: 2
rtecs: DA0670000
ridadr: UN 3077 9 / PGIII
Toxicity: LD50 in rats, mice (mg/kg): >2880, >107200 orally; >2140, >2140 dermally
Signal word: Warning
Symbol(GHS): GHS09
Storage Class: 11 - Combustible Solids
Hazard statements: H362-H410
REACH Registrations: Inactive
Hazard Classifications: Aquatic Acute 1Aquatic Chronic 1Lact.
Precautionary statements: P201-P260-P263-P273-P308+P313-P391

Chemistry & industry

Uses & manufacturing

Household ProductsInformation on 35 consumer products that contain Etofenprox in the following categories is provided:

Use Classification · 2 items

Environmental transformation -> Pesticides (parent, predecessor)

Insecticides

Applications · 3 items

DescriptionEtofenprox belongs to a pyrethroid derivative that is commonly used as an insecticide in agriculture, horticulture, viticulture, forestry, animal health and public health against various insect pests. It can be found as an active ingredient in a variety of pest control products, which is effective to control broad spectrum of pests, such as crawling and flying insects. In the field of agriculture, etofenprox can be applied on a broad range of crops, including rice, fruits, vegetables, corn, soybeans and tea, which is poorly absorbed by roots and little translocation occurs within plants. It is also used for the public health by controlling adult mosquitoes, non biting midges, biting and non-biting flies, which may carry the pathogen. Besides, etofenprox can be found as an component in flea and tick medications for dogs and cats. Etofenprox is a new type of insecticide with low mammalian toxicity, which can be decomposed in soil by anaerobic and aerobic microorganisms. It functions by strongly disrupting the transmission of nervous impulses and causes paralysis and death to the target insect.

UsesEtofenprox is used to control a wide variety of insects on fruit, tea, soyabeans and many vegetables. It is also used in public health and animal health.

UsesInsecticide.

Upstream & downstream products

Upstream raw materials

Suppliers50 total

湖北永阔科技有限公司027-59223108 15972152991 · [email protected]

湖北博杰生物科技有限公司0713-2060728 15629612610

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

湖北万得化工有限公司15377098680 15377098680 · [email protected]

Additional notes

DefinitionChEBI: An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.

Related reactions

12 records

New reaction record

HRID 180569As reactantTraining data from https://doi.org/10.1039/C8SC04228D (6/10)

HRID 185283As reactantTraining data from https://doi.org/10.1039/C8SC04228D (6/10)

HRID 185557As reactantTraining data from https://doi.org/10.1039/C8SC04228D (6/10)

HRID 193609As reactantTraining data from https://doi.org/10.1039/C8SC04228D (6/10)

HRID 1149066As reactantTraining data from https://doi.org/10.1039/C8SC04228D (7/10)

HRID 1719800As reactantuspto-grants-1985_09

HRID 1719801As reactantuspto-grants-1985_09

HRID 2351806As reactantuspto-grants-1989_10

Linked notes

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Basic information