Basic information
- CAS
83184-43-4- Standard SMILES
CC(C)N=CNc1ccc(-c2cnc[nH]2)cc1- InChIKey
GOZUADYOHPCXLE-UHFFFAOYSA-N- Molecular formula
- C13H16N4
- Average molar mass
- 228.29 g/mol
- Monoisotopic mass
- 228.13749653
Overview
Mifentidine is a small molecule drug. The usage of the INN stem '-tidine' in the name indicates that Mifentidine is a histamine- H2-receptor antagonist, cimetidine derivative. Mifentidine has a monoisotopic molecular weight of 228.14 Da.
Names & identifiers
- Preferred name
- Mifentidine
- IUPAC
- N-[4-(1H-imidazol-5-yl)phenyl]-N'-propan-2-ylmethanimidamide
- English name
- Mifentidine
- Molecular weight
- 0
Names & synonyms
Mifentidine83184-43-4MifentidinaMifentidinumDA-45772F70KF5S0KDTXSID002322084(5)-(4-isopropylaminomethyleneiminophenyl)imidazoleRefChem:158839DTXCID60154699Mifentidine [INN]DA 4577
Show more names
N-[4-(1H-imidazol-5-yl)phenyl]-N'-isopropyl-formamidineN-[4-(1H-imidazol-5-yl)phenyl]-N'-propan-2-yl-methanimidamideN2-[4-(1H-Imidazol-4-yl)phenyl]-N1-(1-methylethyl)methanamidineN-[4-(1H-Imidazol-4-yl)phenyl]-N'-(1-methylethyl)methanimidamide
N-(p-Imidazol-4-ylphenyl)-N'-isopropylformamidineN-[4-(1H-imidazol-5-yl)phenyl]-N'-propan-2-ylmethanimidamideMifentidinMifentidinum [Latin]Mifentidina [Spanish]N-[4-(1H-Imidazol-5-yl)phenyl]-N'-(1-methylethyl)methanimidamideUNII-2F70KF5S0KN-(4-(4-Imidazolyl)phenyl)-N'-isopropylformamidin
Database identifiers
- CAS
83184-43-4- PubChem CID
- 71263
- DTXSID
DTXSID00232208- ChEMBL
CHEMBL308005- UNII
- 2F70KF5S0K
- Nikkaji
- J33.098A
Properties
Computed structural properties
- XLogP
- 1.8
- Topological polar surface area
- 53.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 244
Physicochemical properties
- FDA UNII
- 2 F70KF5S0K · 2F70KF5S0K
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Compounds which inhibit or antagonize the biosynthesis or actions of androgens.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Applications
UsesMifentidine (DA 4577) is a potent and selective H2 Receptor antagonist. Mifentidine has an anti-secretion effect and can antagonize the acid-promoting activity of histamine with EC50 3.28 μM[1].
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers6 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
武汉鹏胤药业有限公司13163333255 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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