Basic information
- CAS
95635-56-6- Standard SMILES
COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1.Cl.Cl- InChIKey
RJNSNFZXAZXOFX-UHFFFAOYSA-N- Molecular formula
- C24H35Cl2N3O4
- Average molar mass
- 500.5 g/mol
- Monoisotopic mass
- 499.200462
Overview
See also: Ranolazine (has active moiety).
Names & identifiers
- Preferred name
- Ranolazine Hydrochloride
- IUPAC
- N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide;dihydrochloride
- English name
- Ranolazine dihydrochloride
- Molecular formula
- C24H35Cl2N3O4
- Molecular weight
- 500.46
Names & synonyms
Ranolazine dihydrochloride95635-56-6Ranolazine HClRanolazine hydrochlorideF71253DJUNDTXSID50904741RefChem:178635DTXCID501333851Ranolazine 2HClN-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochlorideRanolazine (dihydrochloride)RS-43285
Show more names
RS 43285RS 43285-193Ranolazine2HclRanolazine DiHCIazine dihydrochLRANOLAZINE DI HCLRanolazine and saltRanolazine dihydroch(±)-Ranolazine-d8 2HCl
Ranolazine hydrochloride [USAN]N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochlorideUNII-F71253DJUNRanolazindihydrochloridMFCD03788770Ranolazine-D8 DihydrochlorideAC-3497N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide;dihydrochloride
Database identifiers
Properties
Computed structural properties
- Topological polar surface area
- 74.3 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 9
- Heavy atoms
- 33
- Formal charge
- 0
- Complexity
- 531
Physicochemical properties
- Melting point
- 222 · 222-229.5 °C(lit.)
- storage temp.
- Desiccate at RT
- solubility
- 2 O: · H2O: 10 mg/mL, soluble
- form
- solid
- color
- off-white
- Water Solubility
- 2 O: · H2O: soluble ≥10mg/mL
- Merck
- 14 · 14,8111
- Stability
- Hygroscopic
- CAS DataBase Reference
- 95635 · 95635-56-6(CAS DataBase Reference)
- FDA UNII
- 71253 DJUN · F71253DJUN
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319
- Precautionary statements
- 264 · P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- Safety Statements
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Safety data
- wgk
- 3
- rtecs
- TK7845370
- hs_code
- 29335990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
Applications
DescriptionRanolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .
UsesRanolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.
Usestreatment of angina and congestive heart failure
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司
Related reactions
2 records
Compound notes
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