Lazabemide

HCID 71307CAS 103878-84-8
Substructure searchFind similar structures

Basic information

Standard SMILES
NCCNC(=O)c1ccc(Cl)cn1
InChIKey
JZXRLKWWVNUZRB-UHFFFAOYSA-N
Molecular formula
C8H10ClN3O
Average molar mass
199.64 g/mol
Monoisotopic mass
199.05123962

Overview

Lazabemide is a small molecule drug. Lazabemide has a monoisotopic molecular weight of 199.05 Da.

Names & identifiers

Preferred name
Lazabemide
IUPAC
N-(2-aminoethyl)-5-chloropyridine-2-carboxamide
English name
LAZABEMIDE
Molecular formula
C8H10ClN3O
Molecular weight
199.64

Names & synonyms

Lazabemide103878-84-8N-(2-aminoethyl)-5-chloropyridine-2-carboxamideLazabemidaRo 19-6327/000DTXSID2048294Ro-19-6327/000420HD787N9Ro-196327lazabemidumRefChem:924579DTXCID3028269
Show more names
Lazabemide hydrateRo 19-6327 hydrateLAZABEMIDE HYDROCHLORIDEN-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide
N-(2-Aminoethyl)-5-chloropicolinamideRo-19-6327CHEMBL2793902-Pyridinecarboxamide, N-(2-aminoethyl)-5-chloro-N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide;N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamideCCRIS 7301NCGC00167737-01Lazabemide [USAN:INN:BAN]

Database identifiers

CAS
103878-84-8
PubChem CID
71307
DTXSID
DTXSID2048294
ChEMBL
CHEMBL279390
UNII
420HD787N9
Nikkaji
J324.183A

Properties

Computed structural properties

XLogP
0.2
Topological polar surface area
68 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
3
Rotatable bonds
3
Heavy atoms
13

Physicochemical properties

Boiling point
397.4 · 397.4±37.0 °C(Predicted)
Density
1.286 · 1.286±0.06 g/cm3(Predicted)
storage temp.
room temp
solubility
22 mg/mL · DMSO: ≥22mg/mL
pka
12.9 · 12.90±0.46(Predicted)
form
powder

Safety & regulation

Safety data

wgk
3
risk_code
22-36
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xn
safety_code
26

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 2 items

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

Applications

UsesTreatment of Alzheimer’s disease.

UsesLazabemide hydrate may be used in cell signaling studies.

Upstream & downstream products

Suppliers46 total

江苏艾康生物医药研发有限公司025-58851090 19370895928 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
InvivoChem中国13549236410 · [email protected]

Related reactions

2 records
New reaction record

Linked notes

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