Basic information
- CAS
33754-49-3- Standard SMILES
Cc1nn(C)c2c1C(c1ccccc1F)=NCC(=O)N2C.Cl- InChIKey
NJERAXSSDSHLGE-UHFFFAOYSA-N- Molecular formula
- C15H16ClFN4O
- Average molar mass
- 322.76 g/mol
- Monoisotopic mass
- 322.099667
Overview
See also: Zolazepam (has active moiety); Tiletamine Hydrochloride; Zolazepam Hydrochloride (component of).
Names & identifiers
- Preferred name
- Zolazepam Hydrochloride
- IUPAC
- 4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[5,4-e][1,4]diazepin-7-one;hydrochloride
- English name
- ZOLAZEPAM HYDROCHLORIDE (500 MG)
- Molecular formula
- C15H16ClFN4O
- Molecular weight
- 322.7651432
Names & synonyms
Zolazepam hydrochlorideZolazepam HCl33754-49-3CI-71645SJ093Q1NPyrazolo(3,4-e)(1,4)diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, monohydrochlorideHydrochloride, ZolazepamRefChem:58788CI716251-668-74-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-e][1,4]diazepin-7(1H)-one monohydrochloride4-(o-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1H)-one monohydrochloride
Show more names
ZOLAZEPAM HYDROCHLORIDE)ZOLAZEPAN HYDROCHLORIDEZOLAZEPAM HYDROCHLORIDE (500 MG)Zolazepam hydrochloride solutionZolazepam Hydrochloride (1724805)Pyrazolo3,4-e1,4diazepin-7(1H)-one, 4-(2-fluorophenyl)-6,8-dihydro-1,3,8-trimethyl-, monohydrochloride
42551-17-7UNII-45SJ093Q1NZolazepam hydrochloride [USAN]4-(2-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo(3,4-e)(1,4)diazepin-7(1H)-one monohydrochloride4-(O-Fluorophenyl)-6,8-dihydro-1,3,8-trimethylpyrazolo[3,4-E][1,4]diazepin-7(1H)-one monohydrochlorideEINECS 251-668-7Zolazepam hydrochloride [USAN:USP]4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[3,4-e][1,4]diazepin-7-one;hydrochloride
Properties
Computed structural properties
- Topological polar surface area
- 50.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 1
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 455
Experimental & physicochemical properties
Animal DrugsFDA approved animal drugs -> Active ingredient
Physicochemical properties
- storage temp.
- -20 °C · -20°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C15H15FN4O.ClH/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9;/h4-7H,8H2,1-3H3;1H
- InChIKey
- NJERAXSSDSHLGE-UHFFFAOYSA-N
- SMILES
- Fc1c(cccc1)C2=NCC(=O)N(c3[n](nc(c32)C)C)C.[Cl-].[H+]
- FDA UNII
- 45 SJ093Q1N · 45SJ093Q1N
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Regulatory InformationZolazepam hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- wgk
- WGK 3
- ridadr
- 3249
- hs_code
- 2933996500
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_class
- 6.1(b)
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- Hazard statements
- H332-H302-H312
- Precautionary statements
- P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Applications
UsesSedative-hypnotic.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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