Acecainide Hydrochloride
Basic information
- CAS
34118-92-8- Standard SMILES
CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1.Cl- InChIKey
IYEWBJUCJHKLHD-UHFFFAOYSA-N- Molecular formula
- C15H24ClN3O2
- Average molar mass
- 313.82 g/mol
- Monoisotopic mass
- 313.1557047
Names & identifiers
- Preferred name
- Acecainide Hydrochloride
- IUPAC
- 4-acetamido-N-[2-(diethylamino)ethyl]benzamide;hydrochloride
- English name
- N-Acetylprocainamide hydrochloride
- Molecular formula
- C15H24ClN3O2
- Molecular weight
- 313.82
Names & synonyms
Acecainide hydrochloride34118-92-8Acecainide HClASL 601ASL-601DTXSID1045748NSC-759312B9K738KX14DTXCID9025748RefChem:108744251-831-2N-ACETYLPROCAINAMIDE HYDROCHLORIDE
Show more names
NAPAACEDAINIDEASL 601(Acecainide)N-ACETYLNOVOCAINAMIDEN-Acecainide hydrochlorideProcainamide N-Acetyl Impurity
4-acetamido-N-(2-(diethylamino)ethyl)benzamide hydrochlorideN-Acetylprocainamide (hydrochloride)N-ACETYLPROCAINAMIDE HClMFCD00012501Acecainide hydrochloride [USAN]4'-((2-(Diethylamino)ethyl)carbamoyl)acetanilide monohydrochlorideSCHEMBL122991SPECTRUM2300154
Database identifiers
- CAS
34118-92-8- PubChem CID
- 71417
- DTXSID
DTXSID1045748- ChEMBL
CHEMBL1256805- UNII
- B9K738KX14
- EC Number
- 251-831-2
Properties
Computed structural properties
- Topological polar surface area
- 61.4 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 7
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 308
Experimental & physicochemical properties
Collision Cross Section170.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 184 · 184-186 °C(lit.)
- storage temp.
- 20 °C · −20°C
- solubility
- 2 O: · H2O: 50 mg/mL
- form
- powder
- color
- Light Beige to Beige
- Water Solubility
- 2 O: · H2O: 50mg/mL
- Merck
- 13 · 13,20
- Stability
- Very Hygroscopic
- InChI
- 1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
- InChIKey
- IYEWBJUCJHKLHD-UHFFFAOYSA-N
- SMILES
- Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
- FDA UNII
- 9 K738KX14 · B9K738KX14
- UNSPSC Code
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- ridadr
- 3249
- hs_code
- 29242998
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 24/25
- hazard_class
- 6.1(b)
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Applications
DescriptionAcecainide, a main metabolite of procainamide, is a class I a antiarrhythmic agent .
UsesCardiac depressant (anti-arrhythmic).
UsesN-Acetylprocainamide Hydrochloride is an antiarrhythmic agent and a metabolite of Procainamide (P755130). Procainamide is a drug used for both supraventricular and ventricular arrhythmias. For example, it can be used to convert new-onset atrial fibrillation, though it is suboptimal for this purpose. It can also be used to treat Wolff-Parkinson-White syndrome by prolonging the refractory period of the accessory pathway.
General DescriptionThe GLC assay procedure was developed to study the stability of N-acetylprocainamide hydrochloride (acecainide hydrochloride) in rat feed.
Suppliers
Loading…
Open inquiries
Loading…
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…