Basic information
- CAS
133314-07-5- Standard SMILES
CN1CCC(C2=C3CCC4C(C5CCN(C)CC5)=c5ccc6n5C5(N34)N3C(=C(C4CCN(C)CC4)c4ccc2n45)CCC3C=6C2CCN(C)CC2)CC1- InChIKey
VTKLWUKNBYRMDP-UHFFFAOYSA-N- Molecular formula
- C45H62N8
- Average molar mass
- 715 g/mol
- Monoisotopic mass
- 714.50974401
Overview
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Names & identifiers
- Preferred name
- FeTMPyP pentachloride
- IUPAC
- 7,12,17,24-tetrakis(1-methylpiperidin-4-yl)-2,22,23,25-tetrazaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3,5,7,12,14,16,21(24)-heptaene
- English name
- FETMPYP
- Molecular formula
- C45H62N8
- Molecular weight
- 715.02738
Names & synonyms
133314-07-5Fe-TMPyPFeTMPyP pentachloride7,12,17,24-tetrakis(1-methylpiperidin-4-yl)-2,22,23,25-tetrazaoctacyclo[11.9.1.11,8.13,21.02,6.016,23.018,22.011,25]pentacosa-3,5,7,12,14,16,21(24)-heptaeneIron(5+), [[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl-kappaN21,kappaN22,kappaN23,kappaN24)tetrakis[1-methylpyridiniumato]](2-)]-, chloride (1:5), (SP-4-1)-SCHEMBL29966009DTXSID90849546C45H62N8MFCD00274429DA-53162G910277,10,13,14-Tetrakis(1-methylpiperidin-4-yl)-1,2,3,7a,8,9-hexahydro-3,4-(metheno)-3a,3c,9b,12b-tetraazacyclopenta[h]-s-indaceno[1,8-ef]acenaphthylene
Show more names
FETMPYPFEIIITMPYP(CL)FE(III)TETRAKIS(1-METHYL-4-PYRIDYL)PORPHYRIN PENTACHLORIDEFe(III) meso-Tetra (N-Methyl-4-Pyridyl) porphine pentachloride5,10,15,20-tetra (1-methyl-4-pyridyl) porphyrin ferric chlorideIron(III) meso -tetra(N-methyl-4-pyridyl)porphine pentachloride5,10,15,20-TETRAKIS(N-METHYL-4'-PYRIDYL)PORPHINATO IRON (III) CHLORIDE
Properties
Computed structural properties
- XLogP
- 3.8
- Topological polar surface area
- 27.6 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 53
- Formal charge
- 0
- Complexity
- 1,590
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 0.1 M · 0.1 M Tris -HCl, 1 mM EDTA, pH 9.0: >12 mg/ml; PBS pH 7.2: >10.1 mg/ml
- form
- A crystalline solid
- color
- Brown to black
- Water Solubility
- 50 mg/mL · water: 50mg/mL
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 335 · H335-H319-H315
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
- WGK Germany
- 1 · WGK 1
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 1
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H335-H319-H315
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Applications
DescriptionFeTMPyP is a synthetic porphyrin complexed with iron, which acts as a peroxynitrite decomposition catalyst. The rate constant for decomposition of peroxynitrite by FeTMPyP is 2.2 x 106 M−1s−1 with a turnover number of 360 ± 170 s−1. The predominant product (>90%) of this reaction is nitrate, with a minor amount of nitrite also formed (~6%), at pH 7.4.
UsesFeTMPyP is an orally active peroxynitrite (ONOO ) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits[1][2].
Suppliers24 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
Aladdin Scientific[email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
重庆星灿医药科技有限公司13594048950 19923294409 · [email protected]
成都安斯利生物医药有限公司028-85305008 02885305008 · [email protected]
吉林中科研伸科技有限公司0431-80534353 19917294565 · [email protected]
普善实业（陕西）有限公司029-81310890 18165209495 · [email protected]
Related reactions
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Compound notes
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