Opipramol Hydrochloride
Basic information
- CAS
909-39-7- Standard SMILES
Cl.Cl.OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1- InChIKey
DLTOEESOSYKJBK-UHFFFAOYSA-N- Molecular formula
- C23H31Cl2N3O
- Average molar mass
- 436.4 g/mol
- Monoisotopic mass
- 435.184418
Overview
See also: Opipramol (has active moiety).
Names & identifiers
- Preferred name
- Opipramol Hydrochloride
- IUPAC
- 2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol;dihydrochloride
- English name
- Opipramol dihydrochloride
- Molecular formula
- C23H31Cl2N3O
- Molecular weight
- 436.41774
Names & synonyms
Opipramol dihydrochloride909-39-7Opipramol hydrochlorideInsidonOpipramol HClDTXSID5045752B49OBI656MG-330401-Piperazineethanol, 4-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)-, dihydrochloride4-(3-(5H-Dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanol dihydrochlorideDTXCID3025752Hydrochloride, Opipramol
Show more names
opipramolhydrochlorideinsidondihydrochlorideOpipramol dihydrochloride >=98% (HPLC), solid4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadicloriOpipramol DihydrochlorideQ: What is Opipramol Dihydrochloride Q: What is the CAS Number of Opipramol Dihydrochloride Q: What is the storage condition of Opipramol Dihydrochloride
RefChem:928242213-000-2Opipramol hydrochloride [USAN]NCGC00093619-02EnsidonPramolan2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol;dihydrochlorideCAS-909-39-7
Database identifiers
- CAS
909-39-7- PubChem CID
- 71587
- DTXSID
DTXSID5045752- ChEMBL
CHEMBL1524185- UNII
- B49OBI656M
- EC Number
- 213-000-2、691-965-2
Properties
Computed structural properties
- Topological polar surface area
- 30 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 448
Experimental & physicochemical properties
Human DrugsBreast Feeding; Lactation; Milk, Human; Antidepressive Agents, Tricyclic; Adrenergic Uptake Inhibitors
Physicochemical properties
- Melting point
- 210 ° · 210° (FR M209); mp 228-230° (DE 1133729)
- solubility
- 2 O: · H2O: ~24 mg/mL
- form
- solid
- color
- yellow
- Water Solubility
- 2 O: · H2O: ~24mg/mL
- InChI
- 1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H
- InChIKey
- DLTOEESOSYKJBK-UHFFFAOYSA-N
- SMILES
- Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1
- FDA UNII
- 49 OBI656M · B49OBI656M
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07,GHS09
- Signal word
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Hazard information
Other Safety InformationIMAP assessments - 1-Piperazineethanol, 4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-, dihydrochloride: Environment tier I assessment
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute Tox. 4 (100%)
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Safety data
- wgk
- 3
- rtecs
- TL9100000
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 22-50/53
- Signal word
- Warning
- Symbol(GHS)
- GHS07,GHS09
- hazard_code
- Xn,N
- safety_code
- 60-61
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Applications
Usesantidepressant, antipsychotic;'sigma antagonist
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…