Piprinhydrinate
Basic information
- CAS
606-90-6- Standard SMILES
CN1CCC(OC(c2ccccc2)c2ccccc2)CC1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O- InChIKey
JSNIFGPPGAINSG-UHFFFAOYSA-N- Molecular formula
- C26H30ClN5O3
- Average molar mass
- 496 g/mol
- Monoisotopic mass
- 495.2037175
Overview
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Names & identifiers
- Preferred name
- Piprinhydrinate
- IUPAC
- 4-benzhydryloxy-1-methylpiperidine;8-chloro-1,3-dimethyl-7H-purine-2,6-dione
- English name
- piprinhydrinate
- Molecular formula
- C19H23NO.C7H7ClN4O2
- Molecular weight
- 0
Names & synonyms
PiprinhydrinateDiphenylpyraline teoclateKoltonPiprinhidrinatoPiprinhydrinatumPiprinhydrinate [INN:BAN]Piprinhydrinatum [INN-Latin]Piprinhidrinato [INN-Spanish]UNII-SI78RFJ7XISI78RFJ7XIEINECS 210-128-0Plokon (TN)
Show more names
8-ChlorotheophyllinateDiphenylpyraline 8-chlorotheophyllinate4-benzhydryloxy-1-methylpiperidine--8-chlorotheophylline (1:1)
Diphenylpyralin-8-chlor-theophyllinat [German]Diphenylpyralin-8-chlor-theophyllinatDiphenylpyraline-8-chlorotheophyllinatePIPRINHYDRINATE [INN]PIPRINHYDRINATE [MART.]Diphenylpyraline teoclate (JAN)PIPRINHYDRINATE [WHO-DD]DTXSID80209413
Database identifiers
- CAS
606-90-6- PubChem CID
- 71640
- DTXSID
DTXSID80209413- UNII
- SI78RFJ7XI
- EC Number
- 210-128-0
Properties
Computed structural properties
- Topological polar surface area
- 81.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 565
Physicochemical properties
- Melting point
- 174 · 174-176°
- FDA UNII
- 78 RFJ7XI · SI78RFJ7XI
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 264 · P264-P270-P301+P312-P330-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Applications
DescriptionPiprinhydrinate is compositon of Diphenylpyraline and 8-chloroteophylline. 8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa. 8-Chlorotheophylline main use is in combination with Diphenylpyraline or diphenhydramine in the antiemetic Piprinhydrinate and dimenhydrinate. Diphenylpyraline (or diphenhydramine) reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help ward off that side-effect.
Upstream & downstream products
Upstream raw materials
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