Basic information
- CAS
1218935-59-1- Standard SMILES
Fc1ccc(F)c([C@H]2CCCN2)c1- InChIKey
NCXSNNVYILYEBC-SNVBAGLBSA-N- Molecular formula
- C10H11F2N
- Average molar mass
- 183.2 g/mol
Names & identifiers
- Preferred name
- 2-(2,5-Difluorophenyl)pyrrolidine, (R)-
- IUPAC
- (2R)-2-(2,5-difluorophenyl)pyrrolidine
- English name
- (2R)-2-(2,5-Difluorophenyl)pyrrolidine
- Molecular formula
- C10H11F2N
- Molecular weight
- 183.2
Names & synonyms
1218935-59-1RPF7VP5RFX2-(2,5-Difluorophenyl)pyrrolidine, (R)-RefChem:1060758(R)-2-(2,5-difluorophenyl)pyrrolidine(2R)-2-(2,5-difluorophenyl)pyrrolidinePyrrolidine, 2-(2,5-difluorophenyl)-, (2R)-MFCD07772701UNII-RPF7VP5RFXSCHEMBL932672SCHEMBL15017136SCHEMBL29404068
Show more names
36. LaronretinibLarotrectinib Pyrrolidine Impurity(2R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE-HCL(2R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochlorideLarotrectinib Impurity 7（Larotrectinib Pyrrolidine Impurity）(2R)-2-(2,5-difluorophenyl)pyrrolidine, (2R,3R)-2,3-bis[(4-methoxybenzoyl)oxy]butanedioic acid
NCXSNNVYILYEBC-SNVBAGLBSA-NAKOS015933481AC-30674DS-11702SY262987DB-289749CS-0055107I11001
Database identifiers
- CAS
1218935-59-1- PubChem CID
- 7176290
- UNII
- RPF7VP5RFX
- EC Number
- 186-338-0
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 12 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 174
Physicochemical properties
- Boiling point
- 213.5 · 213.5±40.0 °C(Predicted)
- Density
- 1.164 · 1.164±0.06 g/cm3(Predicted)
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.02 · 9.02±0.10(Predicted)
- Appearance
- Light yellow to yellow Liquid
- FDA UNII
- 7 VP5RFX · RPF7VP5RFX
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
Uses(2R)-2-(2,5-Difluorophenyl)pyrrolidine is used in the synthesis of imidazo[1,2-b]pyridazine compounds as inhibitors of Trk kinases.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
南京波普生物医药研发有限公司025-87138562 18951783565 · [email protected]
济南百隆化学有限公司
Related reactions
9 records
Compound notes
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