Basic information
- CAS
1240-15-9- Standard SMILES
CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2.Cl- InChIKey
UGVNGSMLNPWNNA-UHFFFAOYSA-N- Molecular formula
- C20H25ClN2OS
- Average molar mass
- 376.9 g/mol
- Monoisotopic mass
- 376.1376123
Overview
Propiomazine Hydrochloride is the hydrochloride salt form of propiomazine, a phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine H1 receptors; Its antipsychotic effect is attributed to antagonistic activities at dopamine and 5-HT2 receptors.
Names & identifiers
- Preferred name
- Propiomazine Hydrochloride
- IUPAC
- 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride
- English name
- Propionylpromazine hydrochloride vetran&
- Molecular formula
- C20H25ClN2OS
- Molecular weight
- 376.94
Names & synonyms
Propiomazine hydrochlorideLargonPropiomazine HCl1240-15-970BO17YR03CHEBI:8492DTXSID808723831-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone monohydrochloride1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one;hydrochloride1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)propan-1-one;hydrochloride1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone monohydrochlorideRefChem:56602
Show more names
PROPIOMAZINE CHLORIDE)UGVNGSMLNPWNNA-UHFFFAOYSA-NPROPIONYLPROMAZINE HYDROCHLORIDE VETRANAPropiomazine D6 hydrochlorideQ: What is Propiomazine D6 hydrochloride Q: What is the CAS Number of Propiomazine D6 hydrochloride Q: What is the storage condition of Propiomazine D6 hydrochloride Q: What are the applications of Propiomazine D6 hydrochloride
DTXCID90820032PROPIONYLPROMAZINE HYDROCHLORIDE VETRAN&1-Propanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-, monohydrochlorideUNII-70BO17YR03Propiomazine hydrochloride [USP]PropiomazinhydrochloridSureCN720224SCHEMBL141677
Properties
Computed structural properties
- Topological polar surface area
- 48.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 441
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- FDA UNII
- 70 BO17YR03 · 70BO17YR03
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Health EffectsThey cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.
Toxicity Summary
Propiomazine is an antagonist at types 1, 2, and 4 dopamine receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.
Signs and Symptoms
Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Chemistry & industry
Pharmacology
Metabolism/MetabolitesUnknown, but most likely hepatic as with other phenothiazines.
Uses & manufacturing
UsesPropiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia.
Applications
UsesPropiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia[1][2].
Suppliers7 total
Chongqing jooe co., ltd+86-15223382610 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
南京世洲生物科技有限公司17301488900 · [email protected]
Shaanxi Dideu Medichem Co. Ltd+86-17392712779 · [email protected]
Related reactions
0 records
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Compound notes
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