Proligestone
Basic information
- CAS
23873-85-0- Standard SMILES
CCC1O[C@]2(C(C)=O)CC[C@@]3(O1)[C@@H]1CCC4=CC(=O)CC[C@]4(C)[C@H]1CC[C@]23C- InChIKey
MQSDUYIXZDSLSZ-QSDCUGRSSA-N- Molecular formula
- C24H34O4
- Average molar mass
- 386.5 g/mol
- Monoisotopic mass
- 386.24570956
Overview
a synthetic progestational steroid; used to suppress ESTRUS
Names & identifiers
- Preferred name
- Proligestone
- IUPAC
- (1R,2R,10R,11S,14S,15R)-15-acetyl-17-ethyl-10,14-dimethyl-16,18-dioxapentacyclo[13.3.2.01,14.02,11.05,10]icos-5-en-7-one
- English name
- proligestone
- Molecular formula
- C24H34O4
- Molecular weight
- 386.52
Names & synonyms
Proligestone23873-85-0DelvosteronProligestonaProligestonumCovinan14 alpha, 17 alpha-propylidenedioxyprogesterone55772LJ01VDTXSID50101668714,17-dihydroxypregn-4-ene-3,20-dione cyclic acetal with propionaldehyde14,17-(Propylidenebis(oxy))pregn-4-ene-3,20-dioneRefChem:868584
Show more names
14,17-[Propylidenebis(oxy)]pregn-4-ene-3,20-dionePregn-4-ene-3,20-dione, 14,17-propylidenebis(oxy)-
DTXCID401474880245-922-6(1R,2R,10R,11S,14S,15R)-15-acetyl-17-ethyl-10,14-dimethyl-16,18-dioxapentacyclo[13.3.2.01,14.02,11.05,10]icos-5-en-7-oneCovinan [veterinary] (TN)Delvosteron [veterinary] (TN)Proligestone (INN)PROLIGESTONE [INN]Proligestone [INN:BAN]
Database identifiers
- CAS
23873-85-0- PubChem CID
- 71906
- DTXSID
DTXSID501016687- ChEMBL
CHEMBL2106696- UNII
- 55772LJ01V
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 52.6 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 2
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 771
Physicochemical properties
- Melting point
- 93 · 93-94 °C
- Boiling point
- 516.1 · 516.1±50.0 °C(Predicted)
- Density
- 1.16 · 1.16±0.1 g/cm3(Predicted)
- solubility
- soluble in No data available
- FDA UNII
- 55772 LJ01V · 55772LJ01V
- Symbol(GHS)
- 7 · GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- 360 · H360-H302-H312-H351-H332
- Precautionary statements
- 201 · P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 19 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationProligestone: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- Signal word
- Danger
- Symbol(GHS)
- GHS07,GHS08
- Hazard statements
- H360-H302-H312-H351-H332
- Precautionary statements
- P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501
Chemistry & industry
Applications
UsesProligestone is a derivative of 17α-Hydroxy Progesterone (H952330), which is a metabolite of Progesterone (P755900), a steroid hormone produced by the corpus luteum. Proligestone maintains the ability to affect the hypothalmic-pituitary-adrenocortical axis and glucose homeostasis.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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