Romifidine
Basic information
- CAS
65896-16-4- Standard SMILES
Fc1cccc(Br)c1NC1=NCCN1- InChIKey
KDPNLRQZHDJRFU-UHFFFAOYSA-N- Molecular formula
- C9H9BrFN3
- Average molar mass
- 258.09 g/mol
- Monoisotopic mass
- 256.99639
Overview
Romifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. It is also used less commonly in a wide variety of other animal species. This drug's chemical structure closely resembles that of clonidine, however, romifidine is not approved for use in humans.
Names & identifiers
- Preferred name
- Romifidine
- IUPAC
- N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
- English name
- Romifidine
- Molecular formula
- C9H9BrFN3
- Molecular weight
- 258.09
Names & synonyms
Romifidine65896-16-4n-(2-bromo-6-fluorophenyl)-4,5-dihydro-1h-imidazol-2-amineRomifidinaSedivetRomifidinum876351L05KDTXSID40216103RefChem:58593DTXCID00138594N-(2-bromo-6-fluorophenyl)-4,5-dihydro-(1H)-imidazol-2-amineMFCD00868606
Show more names
St 2130RomidysSTH 2130Romifidine >2-(2-Bromo-6-fluoroanilino)-2-imidazoline2-(2-Bromo-6-fluorophenylamino)-2-imidazoline1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-
2-(2-Bromo-6-fluoroanilino)-2-imidazolineRomifidine (INN)ROMIFIDINE [INN]Romifidinum [Latin]Romifidina [Spanish]Romifidine [INN:BAN]UNII-876351L05KSedivet (TN)
Database identifiers
- CAS
65896-16-4- PubChem CID
- 71969
- DTXSID
DTXSID40216103- ChEMBL
Properties
Computed structural properties
- XLogP
- 1.4
- Topological polar surface area
- 36.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 234
Experimental & physicochemical properties
Human DrugsPharmaceuticals
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Physicochemical properties
- Melting point
- 110 °C · 110 °C
- Boiling point
- 303.2 · 303.2±52.0 °C(Predicted)
- Density
- 1.72 · 1.72±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 250 mg/mL · DMSO : 250 mg/mL (968.65 mM; Need ultrasonic)
- pka
- 8.69 · 8.69±0.50(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- FDA UNII
- 876351 L05K · 876351L05K
- Comptox DTXSID
- 40216103 · DTXSID40216103
- Symbol(GHS)
- 7 · GHS07
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- hs_code
- 2933.29.2000
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Pharmacology
ATC CodeQN - Nervous system
MeSH Pharmacological Classification
Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesRomifidine is an α2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo[1][2].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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