Basic information
- CAS
81486-22-8- Standard SMILES
CC(C)NCC(O)COc1cccc2c1OCC(O[N+](=O)[O-])C2- InChIKey
OMCPLEZZPVJJIS-UHFFFAOYSA-N- Molecular formula
- C15H22N2O6
- Average molar mass
- 326.34 g/mol
- Monoisotopic mass
- 326.14778643
Overview
Hypadil (TN) is an organic molecular entity.
Names & identifiers
- Preferred name
- Nipradilol
- IUPAC
- [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrate
- English name
- NIPRADILOL
- Molecular formula
- C15H22N2O6
- Molecular weight
- 326.35
Names & synonyms
NipradilolNipradolol81486-22-8HypadilNipradilolumFVM336I71YK-3518-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrateDTXSID308686152H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrateRefChem:927789DTXCID60816705
Show more names
K 351KT 210Ccris 2515Brn 3566879Nipradolol (10mM in DMSO)Hypadil|||Hypadil|||KT 210|||K 351
3,4-dihydro-8-(2-hydroxy-3--isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyranHypadil (TN)[8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-chromen-3-yl] nitrateHypadil; K 351; KT 210; Nipradilo8-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-3,4-dihydro-2H-1-benzopyran-3-yl nitrateNipradilolum [Latin]NipranolNipradilol [INN:JAN]
Database identifiers
- CAS
81486-22-8- PubChem CID
- 72006
- DTXSID
DTXSID30868615
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 106 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 7
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 375
Physicochemical properties
- Melting point
- 110 · 110-122℃
- Boiling point
- 464.39 °C · 464.39°C (rough estimate)
- Density
- 1.1829 · 1.1829 (rough estimate)
- refractive index
- 1.628 · 1.6280 (estimate)
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
- InChI
- InChI=1S/C15H22N2O6/c1-10(2)16-7-12(18)8-21-14-5-3-4-11-6-13(23-17(19)20)9-22-15(11)14/h3-5,10,12-13,16,18H,6-9H2,1-2H3
- InChIKey
- OMCPLEZZPVJJIS-UHFFFAOYSA-N
- SMILES
- C1OC2=C(OCC(O)CNC(C)C)C=CC=C2CC1O[N+]([O-])=O
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 336 I71Y · FVM336I71Y
- Toxicity
- 50 i.v · LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs used to cause dilation of the blood vessels.
Applications
DescriptionNipradilol is a beta-blocker with vasodilatory activity. As an antihypertensive nipradilol decreases systemic/pulmonary arterial blood pressure, heart rate, cardiac output and left ventricular volume without causing tachycardia. Nipradilol is also reported to have antiangina activity in dogs.
UsesNipradolol is a β-adrenoceptor blocking agent with antihypertensive properties.Nipradolol is used as ananti-glaucomatous agent.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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