Basic information
- CAS
101396-42-3- Standard SMILES
C[N+]12CCC(CC1)C(CN1c3ccccc3Sc3ccccc31)C2.[I-]- InChIKey
SWVANDLDSRKJFI-UHFFFAOYSA-M- Molecular formula
- C21H25IN2S
- Average molar mass
- 464.4 g/mol
- Monoisotopic mass
- 464.07832
Overview
derivative of mequitazine
Names & identifiers
- Preferred name
- Mequitamium Iodide
- IUPAC
- 10-[(1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl)methyl]phenothiazine iodide
- English name
- Mequitazium
- Molecular formula
- C21H25IN2S
- Molecular weight
- 464.40607
Names & synonyms
Mequitamium Iodide101396-42-3Mequitazium iodideIoduro de mequitamioIodure de mequitamiumMequitamium iodide [INN]Mequitamii iodidum50D69ZKZ7MUNII-50D69ZKZ7MMequitamii iodidum [INN-Latin]Iodure de mequitamium [INN-French]Ioduro de mequitamio [INN-Spanish]
Show more names
Mequitazium
LG 30435Mequitamii iodidum (INN-Latin)(+-)-1-Methyl-3-(phenothiazin-10-ylmethyl)quinuclidinium iodideIodure de mequitamium (INN-French)Ioduro de mequitamio (INN-Spanish)mequitamio iodurod-Meq cpdRefChem:156531
Database identifiers
- CAS
101396-42-3- PubChem CID
- 72028
- DTXSID
DTXSID50906129- ChEMBL
CHEMBL3989846- UNII
- 50D69ZKZ7M
Properties
Computed structural properties
- Topological polar surface area
- 28.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 437
Physicochemical properties
- FDA UNII
- 50 D69ZKZ7M · 50D69ZKZ7M
Chemistry & industry
Applications
UsesMequitamium iodide (LG 30435) is an antihistamine drug with antiallergic and bronchodilatory activity. Mequitamium iodide can effectively antagonize airway contraction and inflammatory responses induced by histamine and antigens. Mequitamium iodide has nanomolar affinity for the H1 and smooth muscle receptors of histamine and mequitin. Mequitamium iodide, when administered in aerosol form, significantly inhibits histamine- and antigen-induced increases in airway pressure in allergic mice. Mequitamium iodide reduces antigen-induced eosinophil accumulation in the airways. Mequitamium iodide also exhibits inhibitory effects on PAF-induced platelet aggregation and bronchoconstriction, and can be used in the study of allergic diseases such as rhinitis and asthma[1].
Suppliers4 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海德轩医药科技有限公司[email protected] · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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