Basic information
- CAS
110042-95-0- Standard SMILES
CO[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](C(=O)[O-])[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](OC)[C@H](OC(C)=O)[C@@H]8O)[C@H](OC(C)=O)[C@@H]7O)[C@H](OC(C)=O)[C@@H]6O)[C@H](OC(C)=O)[C@@H]5O)[C@H](O)[C@@H]4NC(C)=O)[C@H](OC(C)=O)[C@@H]3O)[C@H](OC(C)=O)[C@@H]2O)[C@H](OC(C)=O)[C@@H]1O- InChIKey
XOYXESIZZFUVRD-UVSAJTFZSA-M- Molecular formula
- C66H100NO49-
- Average molar mass
- 1,691.5 g/mol
- Monoisotopic mass
- 1,690.5363935
Names & identifiers
- Preferred name
- Acemananan
- IUPAC
- (2S,3S,4R,5S,6S)-6-[(2R,3R,4R,5S,6R)-6-[(2R,3S,4R,5S,6R)-5-acetamido-6-[(2R,3R,4R,5S,6R)-4-acetyloxy-6-[(2R,3R,4R,5S,6R)-4-acetyloxy-6-[(2R,3R,4R,5S,6S)-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-3-[(2R,3S,4R,5R,6R)-4-acetyloxy-5-[(2R,3S,4R,5R,6R)-4-acetyloxy-3-hydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxyoxane-2-carboxylate
- English name
- Acemannan
- Molecular formula
- C64H97NO49
- Molecular weight
- 1664.43
Names & synonyms
Acemannanan115426-79-4Acemannan [USAN:INN]Acemannanum [INN-Latin]Acemananan [INN-Spanish]Acemananan115426-79-4 (free base)UNII-UZ29E6L2X8110865-83-3orb1698780AKOS040750050(2S,3S,4S,5S,6S)-6-[(2R,3R,4S,5S,6R)-6-[(2R,3S,4R,5S,6R)-5-acetamido-6 -[(2R,3R,4S,5S,6R)-4-acetylox
Show more names
Ace-mCarrisynAcemannanAids000120Aids-000120PolymannoacetateAloeverose (15 mg)Aloe vera mucilageAcemannan (Technical Grade)Acemannan polysaccharide from Aloe vera
NS00126679T29547(2S,3S,4R,5S,6S)-4-(acetyloxy)-3- {[(2R,3S,4R,5R,6R)-4-(acetyloxy)-5- {[(2R,3S,4R,5R,6R)-4-(acetyloxy)-3-hydroxy-6- (hydroxymethyl)-5-methoxyoxan-2-yl]oxy}-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2R,3R,4R,5S,6R)4-(acetyloxy)-6-{[(2R,3S,4R,5S,6R) -
Properties
Computed structural properties
- XLogP
- -12.2
- Topological polar surface area
- 714 Ų
- Hydrogen bond donors
- 16
- Hydrogen bond acceptors
- 49
- Rotatable bonds
- 38
- Heavy atoms
- 116
- Formal charge
- -1
- Complexity
- 3,250
Physicochemical properties
- FDA UNII
- 29 E6L2X8 · UZ29E6L2X8
Chemistry & industry
Applications
DescriptionAcemannan Hydrogel was marketed in the US as a wound healing agent for the care of ulcers, burns and post-surgical incisions. Acemannan is a complex water soluble polymanno- galacto acetate isolated from Aloe vera by alcohol precipitation and purified by filtration to limit the size of the polysaccharide polymers. Pharmacological studies demonstrated immunostimulatory activity through the activation of monocytes and macrophages triggering enhanced secretion of cytokines such as interferon, interleukins, TNF-alpha, GM-CSF and some prostaglandins. It was proposed that the adjuvant activity of this agent could be partly related to its ability to induce phenotypic and functional maturation of immature dendritic cells. In normal healthy males, acemannan administered orally up to 3200 mg/day for 6 days did not show any acute oral toxicity. Acemannan is currently undergoing clinical trials for the treatment of AIDS.
UsesAntiviral; immunomodulator.
UsesAcemannan is an polysaccharide found in the leaves of Aloe Vera (Aloe barbadensis Miller) plant, and is used in a variety of Aloe Vera products.
Suppliers9 total
上海维亦特生物科技有限公司15317051735 · [email protected]
BOC Sciences16314854226 · [email protected]
BOC Sciences[email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
上海瀚香生物科技有限公司17754423994 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
Related reactions
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Compound notes
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