Basic information
- CAS
4945-47-5- Standard SMILES
CN1CCC(N(Cc2ccccc2)c2ccccc2)CC1- InChIKey
VZSXTYKGYWISGQ-UHFFFAOYSA-N- Molecular formula
- C19H24N2
- Average molar mass
- 280.4 g/mol
- Monoisotopic mass
- 280.19394877
Overview
Bamipine is an aromatic amine.
Names & identifiers
- Preferred name
- Bamipine
- IUPAC
- N-benzyl-1-methyl-N-phenylpiperidin-4-amine
- English name
- BAMIPINE
- Molecular formula
- C19H24N2
- Molecular weight
- 280.41
Names & synonyms
Bamipine4945-47-5N-benzyl-1-methyl-N-phenylpiperidin-4-amineBamipinaBamipinum4-(N-Benzyl-N-phenylamino)-1-methylpiperidineDTXSID5057751Y6BHZ28O921-Methyl-N-phenyl-N-(phenylmethyl)-4-piperidinamineDTXCID6031540N-Phenyl-N-benzyl-4-amino-1-methyl-piperidineRefChem:116415
Show more names
SoventolTaumidrinBAMIPINE USP/EP/BPN-benzyl-N-(1-methyl-4-piperidyl)anilineN-Benzyl-1-methyl-N-phenyl-4-piperidinamine4-(n-benzyl-n-phenylamino)-1-methyl-piperidin
D04AA15R06AX01225-587-2bamipin4-(N-Benzylanilino)-1-methylpiperidinePiperidine, 4-(N-benzyl-N-phenylamino)-1-methyl-PiperamineBamipine (INN)
Database identifiers
- CAS
4945-47-5- PubChem CID
- 72075
- DTXSID
DTXSID5057751- ChEMBL
CHEMBL520400- ChEBI
CHEBI:135165
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 6.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 284
Experimental & physicochemical properties
DrugsPharmaceuticals
LogP2.6
Physicochemical properties
- Melting point
- 115 ° · 115°
- Boiling point
- 413.12 °C · 413.12°C (rough estimate)
- Density
- 0.9608 · 0.9608 (rough estimate)
- refractive index
- 1.8676 · 1.8676 (estimate)
- pka
- 3.34 · pKa 3.34±0.04 (H2O t undened I=0.30(NaCl)) (Uncertain);8.04±0.11(H2O t undened I=0.30(NaCl)) (Uncertain)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 6 BHZ28O92 · Y6BHZ28O92
- ATC code
- 4 AA15,R06AX01 · D04AA15,R06AX01
Chemistry & industry
Pharmacology
ATC Code
D04AA15
R - Respiratory system
D - Dermatologicals
QR - Respiratory system
QD - Dermatologicals
Mechanism of ActionBamipine is an antagonist at histamine H1 receptors, reducing histamine-mediated allergic symptoms.
MeSH Pharmacological ClassificationDrugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
Uses & manufacturing
UsesUse (kg; approx.) in Germany (2009): >100
Applications
UsesBamipine is an antihistamine that has anticholinergic properties. It is also a reagent for dopamine D3 receptor ligands based on scaffolds of biogenic amine GPCR (G protein-coupled receptor) ligands.
Upstream & downstream products
Upstream raw materials
Suppliers3 total
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Shaanxi Didu New Materials Co. Ltd
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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