cis-Diammine (glycolato)platinum
Basic information
- CAS
95734-82-0- Standard SMILES
O=C(O)CO.[NH2-].[NH2-].[Pt+2]- InChIKey
KLNFSAOEKUDMFA-UHFFFAOYSA-N- Molecular formula
- C2H8N2O3Pt
- Average molar mass
- 303.18 g/mol
- Monoisotopic mass
- 303.018286
Overview
See also: Nedaplatin (annotation moved to).
Names & identifiers
- Preferred name
- cis-Diammine (glycolato)platinum
- IUPAC
- azanide;2-hydroxyacetic acid;platinum(2+)
- English name
- Nedaplatin
- Molecular formula
- C2H6N2O3Pt
- Molecular weight
- 301.17
Names & synonyms
Nedaplatin [INN]cis-Diammine (glycolato)platinumNCGC00181152-01cis-Diammine(glycolato-O(sup 1),O(sup 2))platinumPlatinum,O(2))-, (SP-4-3)-Platinum,O(2)]-, (SP-4-3)-CCRIS 4088UNII-8UQ3W6JXANAqupla (TN)Nedaplatin (JAN/INN)Tox21_112756NSC375101
Show more names
254-sAquplaNedaplaitNEDAPLATINNidaplatinNSC 375101DNedaplatin, >=99%Nedaplatin USP/EP/BPNedaplatin (NSC 375101D)cis-diammine(glycolato)platinum(ii)
Platinum, diammine(hydroxy-kappaO)acetato(2-)-kappaO)-, (SP-4-3)-AKOS015854028Platinum, diammine(hydroxyacetato(2-)-O(sup 1),O(sup 2))-, (SP-4-3)-AC-1433NSC-375101CAS-95734-82-0D01416Bis(azanido)[(oxido-kappaO)acetato-kappaO]platinum
Database identifiers
- CAS
95734-82-0- PubChem CID
- 72120
- DTXSID
DTXSID8046878
Properties
Computed structural properties
- Topological polar surface area
- 59.5 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 50.5
Physicochemical properties
- storage temp.
- -20 °C · Inert atmosphere,Store in freezer, under -20°C
- solubility
- 2 O · H2O : 13.6 mg/mL (44.86 mM; Need ultrasonic and warming; DMSO can inactivate Nedaplatin's activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Nedaplatin's activity)
- form
- Powder
- color
- Light yellow to yellow
- InChI
- InChI=1S/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1
- InChIKey
- GRHLMSBCOPRFNA-UHFFFAOYSA-M
- SMILES
- N[Pt+2]1([O-]CC(=O)[O-]1)N
- FDA UNII
- 8 UQ3W6JXAN · 8UQ3W6JXAN
- NCI Drug Dictionary
- nedaplatin
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 280 · P280-P305+P351+P338
- target organs
- Respiratory system
- WGK Germany
- 3 · WGK 3
- Storage Class
- 6.1 A · 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Hazard Classifications
- 2 OralCarc · Acute Tox. 2 OralCarc. 1BEye Irrit. 2Resp. Sens. 1BSkin Irrit. 2Skin Sens. 1BSTOT SE 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- target organs
- Respiratory system
- Hazard statements
- H302
- Hazard Classifications
- Acute Tox. 2 OralCarc. 1BEye Irrit. 2Resp. Sens. 1BSkin Irrit. 2Skin Sens. 1BSTOT SE 3
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionNedaplatin, a novel second generation platinum complex, was marketed in Japan for the treatment of a variety of cancers including: head and neck, small-cell and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder, and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more active than cisplatin against several solid tumors while sharing less nephro- and gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by nedaplatin allows its use in patients with deteriorated renal function.
Usesanticancer
UsesNedaplatin is a platinum complex that has potent antineoplatic activity.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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