Basic information
- CAS
6823-79-6- Standard SMILES
CS(=O)(=O)O.CS(=O)(=O)O.N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1- InChIKey
WRXSODAXJSKMAW-UHFFFAOYSA-N- Molecular formula
- C21H32N4O8S2
- Average molar mass
- 532.6 g/mol
- Monoisotopic mass
- 532.16615634
Overview
Pentamidine Mesylate is the mesylate salt form of pentamidine, a synthetic derivative of amidine, with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interfere with microbial nuclear metabolism by inhibiting DNA, RNA, phospholipid and protein synthesis.
Names & identifiers
- Preferred name
- Pentamidine Mesylate
- IUPAC
- 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;methanesulfonic acid
- English name
- 4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
- Molecular formula
- C21H32N4O8S2
- Molecular weight
- 532.63078
Names & synonyms
LomodinePentamidine mesylatePentamidine dimethanesulfonate863QBB4D0A4,4'-(1,5-Pentanediylbis(oxy))bisbenzenecarboximidamide dimethanesulfonateRefChem:171403229-898-46823-79-6Pentamidine dimesylatePentamidine (dimesylate)LomidineMP-601205 (dimesylate)
Show more names
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;methanesulfonic acidBenzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-, dimethanesulfonate4,4'-(1,5-Pentanediylbis(oxy))bisbenzenecarboxamidine dimethylsulphonatePentamidine dimethylsulfonateEINECS 229-898-4UNII-863QBB4D0APentamidine mesilate
Database identifiers
- CAS
6823-79-6- PubChem CID
- 72196
- DTXSID
DTXSID50987751- UNII
- 863QBB4D0A
- EC Number
- 229-898-4
Properties
Computed structural properties
- Topological polar surface area
- 244 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 10
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 468
Physicochemical properties
- FDA UNII
- 863 QBB4D0A · 863QBB4D0A
- RIDADR
- 3249 · 3249
- HazardClass
- 6.1 · 6.1(b)
- PackingGroup
- III
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- ridadr
- 3249
- hazard_class
- 6.1(b)
- packing_group
- III
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Substances that are destructive to protozoans.
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
Applications
UsesPentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
Suppliers4 total
陕西缔都新材料有限公司029-63373950 17392216152 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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