2-Amino-4-methylphenol
Basic information
- CAS
95-84-1- Standard SMILES
Cc1ccc(O)c(N)c1- InChIKey
ZMXYNJXDULEQCK-UHFFFAOYSA-N- Molecular formula
- C7H9NO
- Average molar mass
- 123.15 g/mol
- Monoisotopic mass
- 123.06841391
Overview
2-amino-4-methylphenol is a brown powder. (NTP, 1992)
Names & identifiers
- Preferred name
- 2-Amino-4-methylphenol
- IUPAC
- 2-amino-4-methylphenol
- English name
- 2-Amino-p-cresol
- Molecular formula
- C7H9NO
- Molecular weight
- 123.15
Names & synonyms
2-Amino-4-methylphenol95-84-12-Amino-p-cresol2-Hydroxy-5-methylaniline3-Amino-4-hydroxytoluene6-Hydroxy-m-toluidine4-Methyl-2-aminophenolPhenol, 2-amino-4-methyl-5-Methyl-2-hydroxyanilinep-Cresol, 2-amino-DTXSID40244881-amino-2-hydroxy-5-methylbenzene
Show more names
O-AMINO-P-METHYLPHENOL2-AMINO-PARA-CRESOL, 97%CRESAMINEO-AMINO-P-CRESOL2-Amino-p-kresol
9ZV2574SER1-HYDROXY-2-AMINO-4-METHYLBENZENENSC-7630NSC-60737DTXCID804488RefChem:85218202-457-32-Amino-4-cresol
Database identifiers
- CAS
95-84-1- PubChem CID
- 7264
- DTXSID
DTXSID4024488- ChEMBL
CHEMBL224282- ChEBI
CHEBI:39713- UNII
- 9ZV2574SER
- EC Number
- 202-457-3
- Nikkaji
- J95.381D
Properties
Computed structural properties
- XLogP
- 1.2
- Topological polar surface area
- 46.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 94.9
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Amino Phenols
DrugsPharmaceuticals -> Listed in ZINC15
LogP1.11
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Boiling PointSublimes (NTP, 1992)
Melting Point279 °F (NTP, 1992)
Vapor Pressure0.00308 [mmHg]
Physical Description
2-amino-4-methylphenol is a brown powder. (NTP, 1992)
Brown solid; [CAMEO] Dark brown crystalline solid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 133 · 133-136 °C(lit.)
- Boiling point
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1.5% (1 of 65) of reports.
Warning
H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 65 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
REACH registered substance: 2-amino-p-cresol (EC: 202-457-3)
Phenol, 2-amino-4-methyl-: Does not have an individual approval but may be used under an appropriate group standard
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available, however it is probably combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and mucous membranes.
Hazards SummaryA skin, eye, and mucous membrane irritant; [NTP] A skin and strong eye irritant; [Sigma-Aldrich MSDS]
Reactive GroupPhenols and Cresols
Reactivity Profile2-AMINO-4-METHYLPHENOL reacts with strong oxidizing agents. (NTP, 1992)
Air and Water Reactions
Chemistry & industry
Uses & manufacturing
UsesUsed as an intermediate for organic chemicals and dyes; [NTP]
General Manufacturing InformationPhenol, 2-amino-4-methyl-: ACTIVE
Applications
Uses2-Amino-4-methylphenol was used in the synthesis of novel functionalized spiropyran derivatives of 2H-1,3-benzoxazinone series.
General DescriptionBrown powder.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
69 records
Compound notes
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