Evt-101
Basic information
- CAS
1189088-41-2- Standard SMILES
Cc1nccn1Cc1cc(-c2ccc(F)c(C(F)F)c2)cnn1.Cl.Cl- InChIKey
OJBLXSPBJMGZDN-UHFFFAOYSA-N- Molecular formula
- C16H15Cl2F3N4
- Average molar mass
- 391.2 g/mol
- Monoisotopic mass
- 390.0625864
Overview
an inhibitor of NMDA receptor GluN2B
Names & identifiers
- Preferred name
- Evt-101
- IUPAC
- 5-[3-(difluoromethyl)-4-fluorophenyl]-3-[(2-methylimidazol-1-yl)methyl]pyridazine;dihydrochloride
- English name
- EVT-101 dihyrochloride
- Molecular formula
- C16H14ClF3N4
- Molecular weight
- 354.76
Names & synonyms
EVT-1011189088-41-2B55T45AA8FEvt1015-(3-(Difluoromethyl)-4-fluorophenyl)-3-((2-methyl-1H-imidazol-1-yl)methyl)pyridazine dihydrochlorideRefChem:139691UNII-B55T45AA8FEVT-101 HClEvt-101 dihyrochlorideEVT-101 hydrochloride5-[3-(difluoromethyl)-4-fluorophenyl]-3-[(2-methylimidazol-1-yl)methyl]pyridazine;dihydrochlorideEVT-101 dihydrochloride
Show more names
C16H15Cl2F3N4orb1738190CHEMBL3545349OJBLXSPBJMGZDN-UHFFFAOYSA-NDTXSID001336448GLXC-15394PXB08841DB05956
Database identifiers
- CAS
1189088-41-2- PubChem CID
- 72941990
- DTXSID
DTXSID001336448- ChEMBL
CHEMBL3545349- UNII
- B55T45AA8F
Properties
Computed structural properties
- Topological polar surface area
- 43.6 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 384
Physicochemical properties
- FDA UNII
- 55 T45AA8F · B55T45AA8F
Chemistry & industry
Pharmacology
Mechanism of Action
EVT 101 penetrates the brain at doses that are well tolerated in man and expected to be clinically relevant, shows activity in areas relevant to pain and, importantly, modulates the activity of specific brain regions during the performance of cognitive tasks relevant to Alzheimer's disease.
Related reactions
0 records
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Compound notes
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