Basic information
- CAS
75558-90-6- Standard SMILES
CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1- InChIKey
NNAIYOXJNVGUOM-UHFFFAOYSA-N- Molecular formula
- C23H29F2N3O
- Average molar mass
- 401.5 g/mol
- Monoisotopic mass
- 401.22786888
Overview
Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia in humans even though the drug was ultimately never clinically adopted for this indication. Alternatively, amperozide's main use lies in veterinary medicine, where it is typically employed to minimize aggression and stress in intensively farmed pigs.
Names & identifiers
- Preferred name
- Amperozide
- IUPAC
- 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
- English name
- Amperozide
- Molecular formula
- C23H29F2N3O
- Molecular weight
- 401.498
Names & synonyms
Amperozide75558-90-6AmperozidaAmperozidum4-[4,4-bis(4-fluorophenyl)butyl]-n-ethylpiperazine-1-carboxamideFG 56060M2W3TAG394-(4,4-Bis(4-fluorophenyl)butyl)-N-ethylpiperazine-1-carboxamide4-(4,4-Bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamideDTXSID6048416RefChem:112276DTXCID4028389
Show more names
4-[4,4-Bis(4-fluorophenyl)butyl]-N-ethyl-1-piperazinecarboxamide1-Piperazinecarboxamide, 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethyl-
CHEBI:180480CHEMBL10799351-Piperazinecarboxamide, 4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl-FG-5606Amperozidum [INN-Latin]Amperozida [INN-Spanish]Amperozide [INN:BAN]UNII-0M2W3TAG39
Database identifiers
- CAS
75558-90-6- PubChem CID
- 73333
- DTXSID
DTXSID6048416- ChEMBL
CHEMBL1079935- UNII
- 0M2W3TAG39
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 35.6 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 461
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Boiling point
- 579.5 · 579.5±50.0 °C(Predicted)
- Density
- 1.151 · 1.151±0.06 g/cm3(Predicted)
- storage temp.
- 4 °C · Store at +4°C
- form
- Solid
- pka
- 14.59 · 14.59±0.20(Predicted)
- color
- White to off-white
- FDA UNII
- 0 M2W3TAG39 · 0M2W3TAG39
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Chemistry & industry
Pharmacology
ATC CodeQN - Nervous system
MeSH Pharmacological Classification
A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents).
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Upstream & downstream products
Upstream raw materials
Suppliers10 total
武汉易泰科技有限公司上海分公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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