Amprolium
Basic information
- CAS
121-25-5- Standard SMILES
CCCc1ncc(C[n+]2ccccc2C)c(N)n1.[Cl-]- InChIKey
LCTXBFGHZLGBNU-UHFFFAOYSA-M- Molecular formula
- C14H19ClN4
- Average molar mass
- 278.78 g/mol
- Monoisotopic mass
- 278.1298243
Overview
Amprolium is an organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle. It has a role as a coccidiostat. It is an organic chloride salt and a pyridinium salt. It contains an amprolium(1+).
Names & identifiers
- Preferred name
- Amprolium
- IUPAC
- 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride
- English name
- Amprolium
- Molecular formula
- C14H19N4.Cl
- Molecular weight
- 278.79
Names & synonyms
amproliumAmprolio2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride71M75T660B1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chlorideCHEBI:85265CocciAidAMPROCIDUMPyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chlorideCocci Cure P FOR POULTRYDTXSID9048140Cocciprol
Show more names
Amprolium HCIAMproliuM, USPAmprolium [INN:BAN]Amprolium USP/EP/BPAMPROLIUM USP 26, BPV 98Venlafaxine Impurity 1-d6amprolium/amprolium hydrochlorideAmprolium 1000 μg/mL in Acetonitrile:Water(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.
AmproMed for CalvesCocciAid for CalvesAmprid FOR CALVESAmprol 128AMPROMED For CattleAmproMed P for PoultryRefChem:57745AmproMed-P FOR POULTRY
Database identifiers
- CAS
121-25-5
Properties
Computed structural properties
- Topological polar surface area
- 55.7 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 19
- Formal charge
- 0
- Complexity
- 246
Experimental & physicochemical properties
Animal Drugs
FDA approved animal drugs -> Active ingredient
Pharmaceuticals -> UK Veterinary Medicines Directorate List
Physicochemical properties
- Melting point
- 246 · 246-248 °C (decomp)
- storage temp.
- 0 · 0-6°C
- solubility
- Soluble in DMSO
- form
- powder
- color
- Crystals from methanol + ethanol
- Stability
- Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
- Major Application
- pharmaceutical small molecule
- InChI
- InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
- InChIKey
- LCTXBFGHZLGBNU-UHFFFAOYSA-M
- SMILES
- C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
- CAS DataBase Reference
- 121 · 121-25-5(CAS DataBase Reference)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2.8% (1 of 36) of reports.
Danger
H361 (97.2%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 36 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationAmprolium: Non hazardous
Other Safety InformationIMAP assessments - Pyridinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride: Environment tier I assessment
Hazard Classes and CategoriesRepr. 2 (97.2%)
Safety data
- wgk
- WGK 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319-H335
- Hazard Classifications
- Resp. Sens. 1Skin Sens. 1
- Precautionary statements
- P261-P280-P301+P312-P302+P352-P305+P351+P338
Chemistry & industry
Pharmacology
ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationAgents useful in the treatment or prevention of COCCIDIOSIS in man or animals.
Applications
DescriptionAmprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
UsesCoccidiostat (for poultry).
UsesAmprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.
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Compound notes
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