Peptide-T
Basic information
- CAS
106362-32-7- Standard SMILES
C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O- InChIKey
IWHCAJPPWOMXNW-LYKMMFCUSA-N- Molecular formula
- C35H55N9O16
- Average molar mass
- 857.9 g/mol
- Monoisotopic mass
- 857.3766767
Overview
Peptide-T is under investigation in clinical trial NCT00000392 (Phase II Study of the Efficacy of Peptide T in Hiv-positive Individuals With Cognitive Impairment.).
Names & identifiers
- Preferred name
- Peptide-T
- IUPAC
- (2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acid
- English name
- Peptide T
- Molecular formula
- C35H55N9O16
- Molecular weight
- 857.86
Names & synonyms
PEPTIDE T106362-32-7peptide-t05DYM3ZS1XHIV Peptide TL-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-YM99OI1N73DTXSID701027151Peptide T, HIVRefChem:171568L-Threonine, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-DTXCID901511403
Show more names
T H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OHALA-SER-THR-THR-THR-ASN-TYR-THR ACETATEAla-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate saltL-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-
L-Threonine, N-(N-(N2-(N-(N-(N-(N-D-alanyl-L-seryl)-L-threonyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thrl-alanyl-l-seryl-l-threonyl-l-threonyl-l-threonyl-l-asparaginyl-l-tyrosyl-l-threoninePeptide T;(2S,3R)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acidH-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OHUNII-05DYM3ZS1XC35H55N9O16
Properties
Computed structural properties
- XLogP
- -8.6
- Topological polar surface area
- 431 Ų
- Hydrogen bond donors
- 16
- Hydrogen bond acceptors
- 17
- Rotatable bonds
- 24
- Heavy atoms
- 60
- Formal charge
- 0
- Complexity
- 1,530
Physicochemical properties
- Boiling point
- 1499.5 · 1499.5±65.0 °C(Predicted)
- Density
- 1.432 · 1.432±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- Soluble in DMSO
- pka
- 3.21 · 3.21±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr
- FDA UNII
- 5 DYM3ZS1X · 05DYM3ZS1X
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
DescriptionPeptide T is an HIV entry inhibitor derived from the envelope glycoprotein gp120 of human immunodeficiency virus. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
UsesPeptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
Suppliers
Loading…
Open inquiries
Loading…
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…