CAS 74784-70-6 2-Amino-5-(trifluoromethyl)pyridine (HCID 735862)

Names & identifiers

Preferred name: 2-Amino-5-(trifluoromethyl)pyridine
IUPAC: 5-(trifluoromethyl)pyridin-2-amine
English name: 5-(Trifluoromethyl)pyridin-2-amine
Molecular formula: C6H5F3N2
Molecular weight: 162.11

Names & synonyms

2-Amino-5-(trifluoromethyl)pyridineRefChem:464492623-444-274784-70-65-(trifluoromethyl)pyridin-2-amine2-Amino-5-trifluoromethylpyridine5-(Trifluoromethyl)-2-pyridinamine2-PYRIDINAMINE, 5-(TRIFLUOROMETHYL)-MFCD00042164EN300-1147572-amino-5 -trifluoromethylpyridine5-(trifluoromethyl)-2-pyridylamine

Show more names

JACS-74784-70-62-Amino-5-(trifLBUTTPARK 43\57-47TIMTEC-BB SBB0055005-(trifluoromethyl)p2-Amino-5-(trifluoromethy...2-Amino-5-trifuoromethylpyridine2-AMine-5-trifluoroMethylpyridine

5-(trifluoromethyl)-2-aminopyridineAKOS000265599FS-10682-Amino-5-(trifluoromethyl)pyridine, 97%5-trifluoromethyl-pyridin-2-ylamine5-(trifluoromethyl)pyridine-2-amine2-Amino-5-Trifluoromethyl Pyridine5-(Trifluoromethyl)-2-pyridinamine; 5-(Trifluoromethyl)pyridine-2ylamine; 5-Trifluoromethyl-2-aminopyridine; (5-Trifluoromethylpyridin-2-yl)amine;

Database identifiers

CAS: 74784-70-6
PubChem CID: 735862
DTXSID: DTXSID70352866
EC Number: 623-444-2
Nikkaji: J2.152.093D

Properties

Computed structural properties

XLogP: 1.5
Topological polar surface area: 38.9 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 5
Rotatable bonds: 0
Heavy atoms: 11
Formal charge: 0
Complexity: 134

Physicochemical properties

Melting point: 45 °C · 45 °C
Boiling point: 90 · 90-92/20mbar
Density: 1 · 1,71g/cm
refractive index: 1 · 1,533
Flash point: 104 °C · 104 °C
storage temp.: 2 · Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 4.55 · 4.55±0.13(Predicted)
color: Off-White
BRN: 4800784 · 4800784
InChI: InChI=1S/C6H5F3N2/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H,(H2,10,11)
InChIKey: RSGVKIIEIXOMPY-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(C(F)(F)F)C=C1
CAS DataBase Reference: 74784 · 74784-70-6(CAS DataBase Reference)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 6 · GHS06
Signal word: Danger
Hazard statements: 301 · H301-H315-H319-H335
Precautionary statements: 301 · P301+P310+P330-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 2 · Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes: Xn,Xi,T
Risk Statements: 20 · 20/21/22-36/37/38-25
Safety Statements: 26 · 26-36/37/39-45-36
RIDADR: 2811 · UN 2811 6.1/PG 3
WGK Germany: 3 · 3
Hazard Note: Irritant
HazardClass: 6.1 · 6.1
PackingGroup: III
HS Code: 29333990 · 29333990
Storage Class: 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: 3 OralEye · Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H301 (96%): Toxic if swallowed [Danger Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 75 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 3 (96%)

Safety data

PPE: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
wgk: 3
ridadr: UN 2811 6.1/PG 3
hs_code: 29333990
risk_code: 20/21/22-36/37/38-25
Signal word: Danger
Symbol(GHS): GHS06
hazard_code: Xn,Xi,T
hazard_note: Irritant
safety_code: 26-36/37/39-45-36
hazard_class: 6.1
Storage Class: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
packing_group: III
target organs: Respiratory system
Hazard statements: H301-H315-H319-H335
Hazard Classifications: Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P301+P310+P330-P302+P352-P305+P351+P338

Chemistry & industry

Applications

Uses2-Amino-5-(trifluoromethyl) is a reagent used in the synthesis of selective inhibitors of urokinase plasminogen activator in a non-cytotoxic form of cancer therapy.