Basic information
- CAS
1605-65-8- Standard SMILES
CN(C)P(=O)(Cl)N(C)C- InChIKey
WYLQARGYFXBZMD-UHFFFAOYSA-N- Molecular formula
- C4H12ClN2OP
- Average molar mass
- 170.58 g/mol
- Monoisotopic mass
- 170.03757731
Names & identifiers
- Preferred name
- N,N,N',N'-Tetramethylphosphorodiamidic chloride
- IUPAC
- N-[chloro(dimethylamino)phosphoryl]-N-methylmethanamine
- English name
- BIS(DIMETHYLAMINO)PHOSPHORYL CHLORIDE
- Molecular formula
- C4H12ClN2OP
- Molecular weight
- 170.58
Names & synonyms
1605-65-8N,N,N',N'-Tetramethylphosphorodiamidic chlorideBis(dimethylamino)phosphinic chlorideRefChem:1090320216-517-1Bis(dimethylamino)phosphoryl ChlorideBis(dimethylamido)phosphoric chloridePhosphorodiamidic chloride, tetramethyl-Bis(N,N-dimethylamino)phosphinic chlorideMFCD00008302bis(dimethylamino)phosphorochloridateN-[chloro(dimethylamino)phosphoryl]-N-methylmethanamine
Show more names
Bis(dimethyLamino)phosphinic chLN,N,N',N'-TetramethylphosBis(N,N-diMethylaMino)phosphinChlorophosphonoylbis(dimethylamine)chlorobis(dimethylamino)oxophosphorus
((CH3)2N)2POClTETRAMETHYLPHOSPHORODIAMIDIC CHLORIDEPhosphorodiamidic chloride, N,N,N',N'-tetramethyl-NSC-30697Bis(dimethylamino)phosphorylchlorideC4H12ClN2OPEINECS 216-517-1bis(dimethylamino)phosphinoyl chloride
Database identifiers
- CAS
1605-65-8
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 23.6 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 125
Experimental & physicochemical properties
SpringerMaterials PropertiesChemical shift
Physicochemical properties
- Boiling point
- 246 · 246-247 °C
- Density
- 1.152 g/mL · 1.152 g/mL at 25 °C(lit.)
- refractive index
- 20 · n20/D 1.466(lit.)
- Flash point
- 230 °F · >230 °F
- storage temp.
- 2 · under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- pka
- -0.04 · -0.04±0.70(Predicted)
- form
- Liquid
- color
- Colorless
- Specific Gravity
- 1.18 · 1.18
- Sensitive
- Moisture Sensitive
- BRN
- 471430 · 471430
- InChI
- InChI=1S/C4H12ClN2OP/c1-6(2)9(5,8)7(3)4/h1-4H3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
P260, P264, P264+P265, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Corr. 1B (100%)
Safety data
- PPE
- Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
- wgk
- 3
- ridadr
- UN 3265 8/PG 2
- hs_code
- 29299090
- risk_code
- 34-37-20/21/22
- Signal word
- Danger
- Symbol(GHS)
- GHS05
- hazard_code
- C
- safety_code
- 26-36/37/39-45
- hazard_class
- 8
- Storage Class
- 8A - Combustible corrosive hazardous materials
- packing_group
- III
- Hazard statements
- H314
- Hazard Classifications
- Eye Dam. 1Skin Corr. 1B
- Precautionary statements
Chemistry & industry
Applications
UsesN,N,N′,N′-Tetramethylphosphorodiamidic chloride was used in the synthesis of (-)-allohedycaryol and C2-symmetric binaphthyl phosphortriamide. It was also used in total synthesis of neohedycaryol.
Upstream & downstream products
Downstream products
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
Related reactions
6 records
Compound notes
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