2-Methoxypyridine (HCID 74201)

Names & identifiers

Preferred name: 2-Methoxypyridine
IUPAC: 2-methoxypyridine
English name: 2-Methoxypyridine
Molecular formula: C6H7NO
Molecular weight: 109.13

Names & synonyms

2-METHOXYPYRIDINE1628-89-3Pyridine, 2-methoxy-GEB38J8108EINECS 216-623-8AI3-62040FEMA NO. 4639DTXSID60862722Pyridine, 2methoxyRefChem:474684DTXCID10811447216-623-8

Show more names

2-Methoxyl pyridine2-Methoxypyridine>2-Methoxypyridine98%2-Methoxypyridine 99%2-Pyridol methyl etherMETHYL 2-PYRIDYL ETHERMethyl pyridin-2-yl ether2-METHOXY PYRIDINE FEMA NO.--------2-Methoxypyridine ISO 9001：2015 REACH

InChI=1/C6H7NO/c1-8-6-4-2-3-5-7-6/h2-5H,1HPyridine, methoxy-2-methoxy-pyridineMFCD0000626293337-21-4methoxypyridineUNII-GEB38J81086-methoxypyridine

Database identifiers

CAS: 1628-89-3、93337-21-4
PubChem CID: 74201
DTXSID: DTXSID60862722
ChEMBL: CHEMBL3274300
UNII: GEB38J8108
EC Number: 216-623-8
Nikkaji: J7.535C

Properties

Computed structural properties

XLogP: 1.4
Topological polar surface area: 22.1 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 8
Formal charge: 0
Complexity: 65.5

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Pyridines

SpringerMaterials Properties15N nuclear magnetic resonance spectrum

LogP1.23

Food AdditivesFLAVORING AGENT OR ADJUVANT -> FDA Substance added to food

Density1.044-1.050 (20º)

Solubility · 2 items

Practically insoluble to insoluble in water

Soluble (in ethanol)

Physicochemical properties

Boiling point: 142 °C · 142 °C (lit.)
Density: 1.038 g/mL · 1.038 g/mL at 25 °C (lit.)
refractive index: 20 · n20/D 1.503(lit.)
FEMA: 4639 · 4639 | 2-METHOXYPYRIDINE
Flash point: 90 °F · 90 °F
storage temp.: Inert atmosphere,Room Temperature
form: Liquid
pka: 3.28 · 3.28(at 20℃)
color: Clear colorless to slightly yellow
Appearance: Colorless to Light yellow clear liquid
Odor: 0.1 %inpropylene · at 0.10%inpropylene glycol. green fermented tea
Water Solubility: INSOLUBLE
JECFA Number: 2156 · 2156
BRN: 108189 · 108189
InChI: 1S/C6H7NO/c1-8-6-4-2-3-5-7-6/h2-5H,1H3
InChIKey: IWTFOFMTUOBLHG-UHFFFAOYSA-N
SMILES: COc1ccccn1
LogP: 1.32 · 1.32
CAS DataBase Reference: 1628 · 1628-89-3(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS): 2 · 2-METHOXYPYRIDINE
FDA UNII: 38 J8108 · GEB38J8108
NIST Chemistry Reference: 2 · Pyridine, 2-methoxy-(1628-89-3)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 2 · GHS02,GHS07
Signal word: Warning
Hazard statements: 226 · H226-H315-H319-H335
Precautionary statements: 210 · P210-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: Xi,F
Risk Statements: 10 · 10-36/37/38
Safety Statements: 26 · 26-36-16
RIDADR: 1993 · UN 1993 3/PG 3
WGK Germany: 3 · 3
HazardClass: 3 · 3
PackingGroup: III
HS Code: 29339900 · 29339900
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 2 Flam · Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
Limited Quantities: 5 L · 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 46 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazards SummaryA skin and strong eye irritant; [Alfa Aesar MSDS] See Pyridine.

Hazard Classes and CategoriesFlam. Liq. 3 (100%)

Safety data

PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 3
ridadr: UN 1993 3/PG 3
hs_code: 29339900
risk_code: 10-36/37/38
Signal word: Warning
Symbol(GHS): GHS02,GHS07
hazard_code: Xi,F
safety_code: 26-36-16
hazard_class: 3
Storage Class: 3 - Flammable liquids
packing_group: III
target organs: Respiratory system
Hazard statements: H226-H315-H319-H335
Limited Quantities: 5.0 L (1.3 gallons) (liquid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Hazard Classifications: Eye Irrit. 2Flam. Liq. 3Skin Irrit. 2STOT SE 3
Precautionary statements: P210-P302+P352-P305+P351+P338

Chemistry & industry

Uses & manufacturing

Use Classification · 2 items

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

Applications · 1 item

Uses2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors.

Upstream & downstream products

Upstream raw materials

2-Fluoropyridine

Downstream products

2-Pyridinol-1-oxide 6-Methoxynicotinaldehyde 7-Chloro-10-(4-hydroxyanilino)-2-methoxy benzo(b)-1,5-naphthy ridine 2-Methoxypyridine-3-boronic acid 2-Methoxy-3-pyridinecarboxaldehyde 4-Amino-2-methoxypyridine (2-Oxopyridin-1(2H)-yl)acetic acid 2-Methoxy-3-methylpyridine 5-Bromo-2-methoxypyridine 2-Acetyl-6-methoxypyridine 97 3-Iodo-2-methoxypyridine 2-Methoxy-3,5-dibromo-pyridine

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Related reactions

80 records

New reaction record

HRID 272594As reactantuspto-grants-2008_11

HRID 302892As reactantTraining data from https://doi.org/10.1039/C8SC04228D (8/10)

HRID 352136As reactantuspto-grants-2004_06

HRID 357504As reactantuspto-grants-1998_11

HRID 379251As reactantuspto-grants-2001_10

HRID 411835As reactantuspto-grants-2003_05

HRID 447039As reactantuspto-grants-2013_07

HRID 451251As reactantuspto-grants-2013_07

Linked notes

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Basic information