Propanedioyl dichloride

HCID 74269
NotesReactions
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Basic information

CAS
1663-67-8
Standard SMILES
O=C(Cl)CC(=O)Cl
InChIKey
SXYFKXOFMCIXQW-UHFFFAOYSA-N
Molecular formula
C3H2Cl2O2
Average molar mass
140.95 g/mol
Monoisotopic mass
139.94318466

Names & identifiers

Preferred name
Propanedioyl dichloride
IUPAC
propanedioyl dichloride
English name
Malonyl chloride
Molecular formula
C3H2Cl2O2
Molecular weight
140.95

Names & synonyms

Malonyl chlorideMalonyl dichloride1663-67-8Propanedioyl dichlorideMalonoyl chlorideMalonic acid dichlorideMalonic acid chlorideMalonoyl dichlorideEINECS 216-772-9NSC 66410DTXSID6061860RefChem:868981
Show more names
PROPANEDIOYL CHLORIDEMalonyl dichloridonyLProdipionylMalonylChloride>
DTXCID8035342216-772-9PDF3ZL8FTKMFCD00000735NSC-66410methane-1,1-dicarbonyl chloridemalonylchloridMalonylchloride

Database identifiers

CAS
1663-67-8
PubChem CID
74269
DTXSID
DTXSID6061860
UNII
PDF3ZL8FTK
EC Number
216-772-9
Nikkaji
J7.548E

Properties

Computed structural properties

XLogP
1.5
Topological polar surface area
34.1 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
2
Rotatable bonds
2
Heavy atoms
7

Experimental & physicochemical properties

SpringerMaterials PropertiesSchoenflies notation

Physicochemical properties

Boiling point
53 · 53-55 °C/19 mmHg (lit.)
Density
1.449 g/mL · 1.449 g/mL at 25 °C (lit.)
refractive index
20 · n20/D 1.465(lit.)
Flash point
117 °F · 117 °F
storage temp.
2 · 2-8°C
solubility
sol most organic solvents

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 67 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationMalonyl dichloride: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesFlam. Liq. 3 (100%)

Safety data

F
8-10
PPE
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk
-
tsca
TSCA listed
ridadr
UN 2920 8/PG 2
hs_code
29171990

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPropanedioyl dichloride: ACTIVE
Applications · 2 items

UsesMalonyl Dichloride is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products.

UsesMalonyl chloride can be used as a reactant for the synthesis of:Alkaloids with tetracyclic cores such as cyclopiamide A and speradine E.6-tetrathiafulvalene(TTF)-polymer by condensation polymerization with TTF-based dihydroxy monomer.N-doped TiO2 films by molecular layer deposition.Alkyne-substituted 1,3-oxazines by reaction with arylpropynamides.It can also be used as a coupling agent in the synthesis of block copolymers by anionic polymerization.

Preparation methods

PreparationMalonyl chloride can be prepared from Malonic Acid and Thionyl Chloride.

Upstream & downstream products

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉欣扬瑞和化学科技有限公司13720274133 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]

Related reactions

64 records
New reaction record

Compound notes

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