Perphenazine dihydrochloride
Basic information
- CAS
2015-28-3- Standard SMILES
Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1- InChIKey
JGTYANSBOIVAMH-UHFFFAOYSA-N- Molecular formula
- C21H28Cl3N3OS
- Average molar mass
- 476.9 g/mol
- Monoisotopic mass
- 475.101867
Names & identifiers
- Preferred name
- Perphenazine dihydrochloride
- IUPAC
- 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;dihydrochloride
- English name
- 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride
- Molecular formula
- C21H28Cl3N3OS
- Molecular weight
- 476.89052
Names & synonyms
Perphenazine dihydrochloride2015-28-3Perphenazine HClEINECS 217-944-6UNII-THW7Y583I9THW7Y583I91-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, dihydrochlorideDTXSID70173977ETHAPERAZINE DIHYDROCHLORIDE4-(3-(2-Chlorophenothiazin-10-yl)propyl)-1-piperazineethanol dihydrochloride1-Piperazineethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, hydrochloride (1:2)PERPHENAZINE DIHYDROCHLORIDE [MI]
Show more names
Perphenazine hydrochloridePerphenazine DiHCl (Fluphenazine Dihydrochloride EP Impurity E DiHCl)Perphenazine D8 DihydrochlorideQ: What is Perphenazine D8 Dihydrochloride Q: What is the CAS Number of Perphenazine D8 Dihydrochloride Q: What is the storage condition of Perphenazine D8 Dihydrochloride Q: What are the applications of Perphenazine D8 Dihydrochloride
1-Piperazineethanol, 4-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-, dihydrochloride1-PIPERAZINEETHANOL, 4-(3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)PROPYL)-, HYDROCHLORIDE (1:2)RefChem:171847DTXCID7096468217-944-6Perphenazine (dihydrochloride)2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;dihydrochloride4-[3-(2-chloro-10h-phenothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride
Database identifiers
- CAS
2015-28-3- PubChem CID
- 74835
- DTXSID
DTXSID70173977- UNII
- THW7Y583I9
- EC Number
- 217-944-6
Properties
Computed structural properties
- Topological polar surface area
- 55.3 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 6
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 463
Physicochemical properties
- color
- Crystals
- FDA UNII
- 7 Y583I9 · THW7Y583I9
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 280 · P280-P305+P351+P338
- Toxicity
- 50 orl-rat: · LD50 orl-rat: 318 mg/kg 27ZQAG -,36,72
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 orl-rat: 318 mg/kg 27ZQAG -,36,72
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
UsesPerphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer cell proliferation, and induces apoptosis. Perphenazine dihydrochloride can be used in the research of mental disease, cancer, inflammation[1][3][5].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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