2-Amino-6-chlorobenzoic acid (HCID 75071)

Names & identifiers

Preferred name: 2-Amino-6-chlorobenzoic acid
IUPAC: 2-amino-6-chlorobenzoic acid
English name: 2-Amino-6-chlorobenzoic acid
Molecular formula: C7H6ClNO2
Molecular weight: 171.58

Names & synonyms

2-Amino-6-chlorobenzoic acid2148-56-3DTXSID401757616CABA cpdRefChem:85309DTXCID1098252218-416-86-Chloroanthranilic acidMFCD00051530Benzoic acid, 2-amino-6-chloro-2-amino-6-chloro-benzoic acid6-Chloranthranilsaure

Show more names

LAQU-001RARECHEM AL BO 1514TIMTEC-BB SBB0017352-Amino-6-chlorobenz6-chloro-2-aMino acidAMino-6-chlorobenzoic acid6-AMINO-2-CHLOROBENZOC ACID2-choro-6-Aminobenzoic Acid2 mino-6-chlorobenzoic acid

NSC171896-chloro anthranilic acid2Amino-6-chlorobenzoic acidSCHEMBL1474372-amino-6-chloro benzoic acidorb2939778SCHEMBL1803965CS-D1462

Database identifiers

CAS: 2148-56-3
PubChem CID: 75071
DTXSID: DTXSID40175761
EC Number: 218-416-8
Nikkaji: J80.401K

Properties

Computed structural properties

XLogP: 1.5
Topological polar surface area: 63.3 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 3
Rotatable bonds: 1
Heavy atoms: 11
Formal charge: 0
Complexity: 163

Physicochemical properties

Melting point: 158 · 158-160 °C (lit.)
Boiling point: 250 °C · 250°C (rough estimate)
Density: 1.3246 · 1.3246 (rough estimate)
refractive index: 1.556 · 1.5560 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 0.97 · 0.97±0.10(Predicted)
form: Crystalline Powder
color: Light yellow to beige
Water Solubility: Very soluble in water. Soluble in methanol.
BRN: 2804041 · 2804041
Major Application: peptide synthesis
InChI: InChI=1S/C7H6ClNO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey: SZCPTRGBOVXVCA-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=C(Cl)C=CC=C1N
CAS DataBase Reference: 2148 · 2148-56-3(CAS DataBase Reference)
NIST Chemistry Reference: 2 · 2-Amino-6-chlorobenzoic acid(2148-56-3)
UNSPSC Code: 12352106 · 12352106
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36-37/39
WGK Germany: 3 · 3
Hazard Note: Irritant
HS Code: 29224999 · 29224999
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 54 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationStatus: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/26144

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
hs_code: 29224999
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
hazard_note: Irritant
safety_code: 26-36-37/39
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
REACH Registrations: Active
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Applications

Uses2-Amino-6-chlorobenzoic acid is used as intermediate for medicine.

Preparation methods · 1 item

PreparationA, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h；B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2).