HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylhydrazine
Phenyl hydrazide · Fenilidrazina · phenyl-hydrazin · Phenylhydrazine,95% · Phenyldiazane · JACS-100-63-0 · Fenylhydrazine · Phenylhydrazin
Identifiers & Physical Properties
| CAS No. | 100-63-0 |
|---|---|
| Molecular formula | C6H8N2 |
| Average molar mass | 108.14 g/mol |
| Monoisotopic mass | 108.06874826 g/mol |
| SMILES | NNc1ccccc1 |
| InChIKey | HKOOXMFOFWEVGF-UHFFFAOYSA-N |
| PubChem CID | 7516 |
| ChEMBL | CHEMBL456807 |
| ChEBI | CHEBI:27924 |
| EC No. | 202-873-5 |
| DTXSID | DTXSID8021147 |
Chemical & Physical Properties
| XLogP | 1.2 |
|---|---|
| Topological polar surface area | 38.1 |
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 1 |
| Heavy atoms | 8 |
| Formal charge | 0 |
| Complexity | 57.5 |
| Chemical classes | Nitrogen Compounds -> HydrazinesFlammable agents - 2nd degree |
| SpringerMaterials Properties | 13C nuclear magnetic resonance spectrum |
| LogP (partition coefficient) | log Kow= 1.25 |
| Odor | Faint, aromatic odor. |
| Density | 1.0978 (USCG, 1999) - Denser than waterwill sink1.0978 at 20 °C/4 °CRelative density (water = 1): 1.11.0978 @ 20°C1.101.098 g/mL at 25 °C (lit.) |
| Color/Form | Monoclinic prisms or oilColorless to pale yellow liquid or solid (below 67 degrees F). |
| Solubility | Slight (NIOSH, 2024)Sparingly sol petroleum ether, sol in dil acids. Miscible in alcohol, ether, chloroform, and benzeneSoluble in oxygenated, chlorinated, and aromatic solvents.Very soluble in acetone.In water, 1.27X10+5 mg/L at 25 °CSolubility in water, g/100ml at 25 °C: 14.5Soluble in dilute acids.145 g/L (20 ºC) |
| Flash point | 190 °F (USCG, 1999)88 °C190 °F, 88 °C (closed cup)88 °C c.c.192 °F |
| Boiling point | 471 °F at 760 mmHg (with decomposition) (USCG, 1999)243.5 °C, decomp (760 mm Hg)173.5 °C at 100 mm Hg148.2 °C at 40 mm Hg131.5 °C at 20 mm Hg115.8 °C at 10 mm Hg101.6 °C at 5 mm Hg71.8 °C at 1 mm Hg470 °F (decomposes)243.5 °C @760 [mm Hg]238-241 °C (lit.) |
| Decomposition | When heated to decomposition it emits highly toxic fumes of /nitrogen oxides/.243.5 °C |
| Melting point | 68 °F (USCG, 1999)19.5 °CMP: 243-6 °C, decomposesmolecular wt 144.60 /Phenylhydrazine hydrochloride/Liquid Molar Volume= 0.098820 cu m/kmolIG Heat of Formation= 2.0350X10+8 J/kmolHeat of Fusion at the Melting Point= 1.6429X10+7 J/kmol.67 °F18-21 °C (lit.) |
| Vapor density | 3.7 (air= 1)Relative vapor density (air = 1): 3.74.3 (vs air) |
| Vapor pressure | <0.1 mm Hg ( 20 °C) |
| Refractive index | n20/D 1.607(lit.) |
| Storage conditions | Store below +30°C. |
| Physical state | Powder |
| pKa (acidity coefficient) | 8.79(at 15℃) |
| Color | White to slightly blue or light beige |
| Explosive limits | 1.1%(V) |
| Specific heat capacity | Cp(liquid): 2.01 J/(g·K), at 25℃ |
| Sensitivity | Air & Light Sensitive |
| Merck | 14,7293 |
| BRN | 606080 |
| Henry's law constant | 2.2×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Exposure limits | ACGIH:TLV-TWA 0.1 ppm (0.44 mg/m3)OSHA:PEL-TWA 5 ppm (22 mg/m3)NIOSH:REL-Ceiling 0.14 ppm [2-hr] |
| Dielectric constant | 7.2(23℃) |
| Stability | Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides. |
| InChI | 1S/C6H8N2/c7-8-6-4-2-1-3-5-6/h1-5,8H,7H2 |
| InChIKey | HKOOXMFOFWEVGF-UHFFFAOYSA-N |
| SMILES | NNc1ccccc1 |
| CAS DataBase Reference | 100-63-0(CAS DataBase Reference) |
| FDA UNII | 064F424C9K |
| NIST Chemistry Reference | Hydrazine, phenyl-(100-63-0) |
| EPA Substance Registry System | Phenylhydrazine (100-63-0) |
| UNSPSC Code | 12352127 |
| NACRES | NA.22 |
| GHS pictogram | GHS06,GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H310-H301+H331-H315-H319-H370-H372-H317-H341-H350-H400-H227 |
| GHS precautionary statements | P501-P273-P272-P270-P262-P202-P260-P210-P201-P271-P264-P280-P370+P378-P391-P337+P313-P305+P351+P338-P308+P311-P361+P364-P333+P313-P301+P310+P330-P302+P352+P310-P304+P340+P311-P403+P233-P403+P235-P405 |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard symbols | T,N |
| Risk statements (R) | 45-23/24/25-36/38-43-48/23/24/25-50-68 |
| Safety statements (S) | 53-45-61 |
| Occupational exposure limit (OEL) | Ceiling: 0.14 ppm (0.6 mg/m3) [2-hr] [skin] |
| UN transport number | UN 2572 |
| Water hazard class (WGK) | 3 |
| RTECS number | MV8925000 |
| F | 8-10-23 |
| Autoignition temperature | 345 °F |
| TSCA inventory status | TSCA listed |
| Customs code | 2928 00 90 |
| Hazard class | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Carc. 1BEye Irrit. 2Muta. 2Skin Irrit. 2Skin Sens. 1STOT RE 1 |
| Packing group | II |
| Storage class | 6.1A - Combustible, acute toxic Cat. 1 and 2very toxic hazardous materials |
| Hazardous substances data | 100-63-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 188 mg/kg |
| Immediately dangerous to life or health concentration | 15 ppm |
| REACH registrations | Active |
| Limited quantities | 0.5 Kg (solid) |
| Excepted quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
Safety & Regulations
| GHS classification | DangerH301: Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Regulatory information | Chemical: Hydrazine, phenyl-Hydrazine, phenyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Hydrazine, phenyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 01-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14149Phenylhydrazine: HSNO Approval: HSR003056 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| Other safety information | IMAP assessments - Phenylhydrazine and its monohydrochloride: Human health tier II assessment |
| DOT label | Poison |
| Fire hazards | Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire.· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 88 °C explosive vapour/air mixtures may be formed. |
| Fire potential | Flammable when exposed to heat, flame, or oxidizers. |
| Health hazards | Material is corrosive to tissue. Exposure can cause vomiting, diarrhea, fatigue, headache, and irritation and itchiness of the eyes and skin. (USCG, 1999)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
| Hazards summary | Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization[ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure[CHRIS] |
| DOT ID and guide | 2572 153 |
| Reactive group | Azo, Diazo, Azido, Hydrazine, and Azide Compounds |
| EC classification | Symbol: T, NR: 45-23/24/25-36/38-43-48/23/24/25-68-50S: 53-45-61Note: E |
| UN classification | UN Hazard Class: 6.1UN Pack Group: II |
| Special Reports | International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Available from http://www.inchem.org/pages/cicads.html Number 19: Phenyl hydrazine as of April 16, 2004. |
| Fire fighting | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Use water spray, alcohol-resistant foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| First aid measures | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . |
| Accidental release measures | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| First aid | Excerpt from NIOSH Pocket Guide for Phenylhydrazine:General First Aid:(General first aid procedures) |
| Safe storage | Separated from strong oxidants and food and feedstuffs. Store in an area without drain or sewer access. |
| Exposure control and personal protection | · Wear positive pressure self-contained breathing apparatus (SCBA). |
| Storage conditions | Keep well closed and protected from lightSince they are strong reducing agents, they are hypergolic when in contact with strong oxidizers ... /Hydrazine derivatives/All hydrazines should be stored at temperatures well below their boiling points. Hydrazines that are ignitable shall be stored in electrically grounded containers and isolated from ignition sources and oxidants. All containers of hydrazines shall be kept tightly closed when not in use and stored in a cool ventilated room or sheltered outside space. In the containers, a blanket of nitrogen or other inert gas should be placed over the hydrazines. |
| Nonfire spill response | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: |
| Disposal methods | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
| Spillage disposal | Evacuate danger area! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. If liquid: collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. If solid: sweep spilled substance into containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.... Should be used only in well ventilated premises and cumulative action of repeated small doses should be avoided.Inhalation of salt dusts should be avoided. /Hydrazine & derivatives/For more Preventive Measures (Complete) data for PHENYLHYDRAZINE (9 total), please visit the HSDB record page. |
| Isolation and Evacuation | Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:Immediate precautionary measure |
| Cancer Sites | [in animals: tumors of the lungs, liver, blood vessels & intestine] |
| Interactions | Erythrocytes (RBC) from phenylhydrazine treated mice are protective when injected into syngenic mice before x-ray irradiation. Evidence suggested that repair of hemopoietic stem cells was enhanced in mice injected with phenylhydrazine red blood cells before x-ray irradiation.The protective effect of phenylhydrazine hydrochloride (PHCL) against acute deaths resulting from whole body irradiation was examined in mice. Male (C3H/C57Bl)F1 mice received sc 1 mg PHCL in 0.1 mL water for 3 days. Controls received injections of water. Mice were injected ip with (59)iron as citrate 1 to 10 days after 3rd PHCL injection. Some mice were exposed to 800 roentgens at various intervals after 3rd injection. During the 1st five days, PHCL caused increases in spleen wt and (59)iron uptake in erthyrocytes and spleen, but a reduction in (59)iron uptake in femurs. All values returned to those of controls by 10 days after 3rd injection. Thirty-day survival of water injected control was 10%. Pretreatment with PHCL improved 30-day survival to almost 100% when mice were irradiated between 4 and 8 days after 3rd injection. Apparently the improved survival resulted from an increase in the number of hemopoietic stem cells at time of irradiation. /Phenylhydrazine hydrochloride/The peroxidation induced by phenylhydrazine in rats chronically exposed to lead was evaluated. Wistar-rats were exposed to lead in-utero and up to four months after birth via administration of distilled drinking water containing ...lead-acetate. The animals were then maintained in a closed desiccator system for analysis of exhaled hydrocarbons before or immediately after injection of phenylhydrazine. The effect of chronic lead pretreatment was assessed by measuring the production of the four main volatile hydrocarbons: ethane and pentane as indices of lipid peroxidationpropane as a marker of protein peroxidationand ethylene as an index of both lipid and protein peroxidations. Lead alone did not increase the physiological formation of alkanes. After phenylhydrazine injection, lipid peroxidation markers were not modified except for pentane in male lead treated rats. Ethylene and propane exhalation, on the other hand, were increased 45 minutes after phenylhydrazine injection in lead treated rats, indicating lead induced potentiation of the oxidative effect of phenylhydrazine. |
| Target organs | Blood, respiratory system, liver, kidneys, skin |
| Ecotoxicity values | LC50 Brachydanio rerio (Zebrafish) 0.16-0.26 mg/L/96 hr /Conditions of bioassay not specified in source examined/EC50 Daphnia sp. (Water fleaintoxication, immobilization) <1200 ug/L 24 hrstaticLC50 Oryzias latipes (Medaka) 21,400 ug/L/24 hr, 15,700 ug/L/48 hr |
| Environmental fate | TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 110(SRC), determined from a measured log Kow of 1.25(2) and a recommended regression-derived equation(3), indicates that phenylhydrazine will have high mobility in soil(SRC). Phenylhydrazine is a weak base with a pKa of 5.21(4), suggesting it will partially exist as a cation in moist soil, and the cationic form may adsorb to soil more than the free base(SRC). Phenylhydrazine is not expected to volatilize from moist soil surfaces(SRC)because cations do not volatilize and the Henry's Law constant of the free base is estimated as 2.9X10-8 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure, 0.026 mm Hg(5), and water solubility, 1.27X10+5 mg/L(6). In the Zahn-Wellens aqueous screening test, 85% of this compound was biodegraded in 9-13 days(7). Phenylhydrazine may be susceptible to photolysis upon exposure to sunlight on soil surfaces as it strongly absorbs UV light in the environmentally significant range (wavelengths >290 nm)(8).AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 110(SRC), determined from a measured log Kow of 1.25(2) and a recommended regression-derived equation(3), indicates that phenylhydrazine should not adsorb to suspended solids and sediment in water(SRC). Phenylhydrazine is a weak base with a pKa of 5.21(4), suggesting it will partially exist as a cation in water, and the cationic form may adsorb to sediment more than the free base(SRC). Phenylhydrazine is not expected to volatilize from water surfaces(3)because cations do not volatilize and the Henry's Law constant of the free base is estimated as 2.9X10-8 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure, 0.026 mm Hg(5), and water solubility, 1.27X10+5 mg/L(6). According to a classification scheme(7), an estimated BCF value of 2(SRC), from a measured log Kow(2) and regression derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Based on limited data, phenylhydrazine may biodegrade under aerobic conditions in natural water environments(SRC). In the Zahn-Wellens aqueous screening test, 85% of this compound was biodegraded in 9-13 days(9). Phenylhydrazine is not expected to undergo hydrolysis as it lacks hydrolyzable functional groups, but may be susceptible to photolysis upon exposure to sunlight in natural waters because it strongly absorbs UV light in the environmental UV spectrum (wavelengths >290 nm)(10).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), phenylhydrazine, which has a measured vapor pressure of 0.026 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase phenylhydrazine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be about 9 hours(SRC), calculated from its rate constant of 4.3X10-11 cu cm/molecule-sec at 25 °C(SRC) estimated with a structure estimation method(3). |
| Adverse effects | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Exposure routes | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
| Toxicity summary | IDENTIFICATION: Phenylhydrazine exists as yellow to brown crystals or as a yellowish oily liquid. This chemical is used world wide mainly as a chemical intermediate in the pharmaceutical, agrochemical and chemical industries. HUMAN EXPOSURE: The number of persons potentially exposed to phenylhydrazine or its hydrochloride salt is unknown, but is expected to be small. No personal exposure data were available. There is evidence that phenylhydrazine has skin sensitizing properties in humans. There are no adequate data available regarding the reproductive or developmental effects, hence, it is not possible to evaluate the risk to human health for these endpoints. The level of risk in occupational settings is uncertainas a result, there is a continuing requirement to reduce exposure levels with the technology currently available. The lack of available data to serve as a basis for estimation of indirect exposure of individuals to phenylhydrazine from the general environment precludes the characterization of potential cancer risks for the general population. ANIMAL/PLANT STUDIES: The limited data on the toxicokinetics indicate that phenylhydrazine is well absorbed by inhalation, oral and dermal routes and binds readily with hemoglobin in red blood cells. Metabolism seems to occur via ring hydroxylation and conjugation, probably with glucuronic acid. Excretion is primarily via the urine. Phenylhydrazine is toxic by single exposure via the oral route (LD50 80-188 mg/kg body weight) and is expected to be toxic by inhalation and dermal routes (data from these routes are less clear). Phenylhydrazine has potential for skin and eye irritation. Exposure to this chemical may cause damage to red blood cells, potentially resulting in anemia and consequential secondary involvement of other tissues such as the spleen and liver. Phenylhydrazine is mutagenic in vitro, and there is some evidence to indicate that it may express genotoxic activity in vivo. The substance is clearly carcinogenic in mice following oral dosing, inducing tumors of the vascular system. Phenylhydrazine is readily biodegradable. Phenylhydrazine is toxic to aquatic organisms, with the lowest reported no observed effect concentration (NOEC) in standard acute fish tests at 0.01 mg/lfish are generally more sensitive than either daphnids or bacteria. A NOEC of 0.49 ug/l has been reported for embryo larval stages of the zebra fish (Brachydanio rerio). |
| Ecotoxicity excerpts | /AQUATIC SPECIES/ The toxicities of hydrazine and phenylhydrazine to embryos and larvae of zebrafish, Brachydanio rerio, were studied under standardized conditions. Exposures to the chemicals started at the blastula stage and the effect on hatching and survival were monitored for 15 days. The results showed that toxicities of phenylhydrazine to both embryos and larvae were more than those of hydrazine. The Lowest Observed Effect Concentration for hatching was 0.049 mg/L for hydrazine and 0.0078 mg/L for phenylhydrazine, the Lowest Observed Effects Concentration for survival of larvae was 0.0035 mg/L for hydrazine and 0.00098 mg/L for phenylhydrazine, respectively. The No Observed Effect Concentration for hatching was 0.0245 mg/L for hydrazine and 0.0039 mg/L for phenylhydrazine and the No Observed Effect Concentration for survival of larvae was 0.00175 mg/L for hydrazine and 0.00049 mg/L for phenylhydrazine, respectively./AQUATIC SPECIES/ In a study on the goldfish (Carassius auratus), 40% of fish died when exposed to phenylhydrazine at a nominal concentration of 1 mg/L for 48 h. Signs of toxicity included erratic swimming, sinking to the bottom of the test tank, and slowed and erratic respiration. No gross lesions were found following dissection, although all viscera showed focal hemorrhaging./AQUATIC SPECIES/ Effects on blood cells and the hematopoietic system, comparable to those found in mammals, were seen in fish injected with phenylhydrazine. Chinook salmon (Oncorhynchus tshawytscha) juveniles were injected with 12.5 mg phenylhydrazine/kg body weight. Red cell count, hemoglobin, and hematocrit fell to 1-5% of their normal values within 10 days of treatmenta slight improvement was reported 15 days following injection, and values had returned to normal 95 days after treatment. |
| Signs and Symptoms | Cough. Sore throat. Weakness. Dizziness.MAY BE ABSORBED! Dry skin. Redness. Pain.Redness. Pain. Blurred vision.Abdominal pain. Diarrhoea. Dizziness. Nausea. Vomiting. Weakness.Skin sensitization, hemolytic anemia, dyspnea (breathing difficulty), cyanosisjaundicekidney damagevascular thrombosis[potential occupational carcinogen] |
| ICSC Environmental Data | The substance is toxic to aquatic organisms. |
| Medical Surveillance | ... Situations in which air concentration ... approach 5 ppm and particularly where there is additional possibility of skin contact, workers should be under careful medical observation.It is essential that alcoholics or persons suffering from liver ailments or blood disorders are ... /protected/ from work with phenylhydrazine. Complete periodic medical exam should including blood tests, as well as biochemical tests (glycemia, cholesterolemia, bilirubinemia). Urine should be exam ... for the degradation products of phenylhydrazine. |
| TSCA requirements | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Phenylhydrazine is included on this list. |
| F | 8-10-23 |
| Occupational exposure limit (OEL) | Ceiling: 0.14 ppm (0.6 mg/m3) [2-hr] [skin] |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Water hazard class (WGK) | 3 |
| Immediately dangerous to life or health concentration | 15 ppm |
| TSCA inventory status | TSCA listed |
| RTECS number | MV8925000 |
| UN transport number | UN 2572 |
| Customs code | 2928 00 90 |
| Toxicity | LD50 orally in Rabbit: 188 mg/kg |
| Risk statements (R) | 45-23/24/25-36/38-43-48/23/24/25-50-68 |
| Signal word | Danger |
| GHS pictogram | GHS06,GHS08,GHS09 |
| Hazard symbols | T,N |
| Safety statements (S) | 53-45-61 |
| Hazard class | 6.1Acute Tox. 3 DermalAcute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Carc. 1BEye Irrit. 2Muta. 2Skin Irrit. 2Skin Sens. 1STOT RE 1 |
| Storage class | 6.1A - Combustible, acute toxic Cat. 1 and 2very toxic hazardous materials |
| Packing group | II |
| GHS hazard statements | H310-H301+H331-H315-H319-H370-H372-H317-H341-H350-H400-H227 |
| Limited quantities | 0.5 Kg (solid) |
| Excepted quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
| REACH registrations | Active |
| Autoignition temperature | 345 °F |
| GHS precautionary statements | P501-P273-P272-P270-P262-P202-P260-P210-P201-P271-P264-P280-P370+P378-P391-P337+P313-P305+P351+P338-P308+P311-P361+P364-P333+P313-P301+P310+P330-P302+P352+P310-P304+P340+P311-P403+P233-P403+P235-P405 |
| Hazardous substances data | 100-63-0(Hazardous Substances Data) |
Applications & Uses
Uses
In the field of pesticide production, phenylhydrazine can be used for synthesizing the intermediate 1-phenyl-semicarbazide of the organophosphorus pesticides, triazophos as well as the intermediate 1-phenyl-3, 6-hydroxy pyridazine of pyridaphenthione. It is also the intermediates of the novel bactericidal varieties, famoxadone and fenamidone. In addition, hydrazine benzene, as a raw material for organic synthesis, can also be used as the intermediates of dye and pharmaceutical industry as well as being used as an analytical reagent. The product is the intermediate of dye, pharmaceuticals and pesticides. It can be used for the production of Naphthol AS-G, drugs such as antipyrine and so on. Dissolving the phenylhydrazine in 95% ethanol and following by addition of benzaldehyde and reflux for 1 h can obtain the phenylhydrazone. Phenylhydrazone can also be used as the intermediate of organic synthesis. Phenylhydrazine is also used as an analytical reagent. As a weak base, it can be used to precipitate lead, chromium and other trivalent, tetravalent element in the form of hydroxide. It can also be used for photometric determination of aluminum, chromium, copper, molybdenum, titanium, and zirconium. It can also be used for verification of gold, iridium, molybdenum, palladium, platinum, and silver. It can be used as the reducing agent for colorimetric assay of phosphorus acid. It can also react with aldehydes, ketones and sugars to get phenylhydrazone with different melting points according which we will be able to identify these substances.
Uses
Phenylhydrazine, as hydrochloride solution plus sodium acetate, reacts with polyhydroxy aldehydes or ketones yielding osazones or diphenylhydrazones, yellow solids, of definite melting point and utilized in identification of sugars, e.g., phenyl-d-glucosazone, CH2OH (CHOH)3C: (NNHC6H5)CH:(NNHC6H5) plus aniline C6H5NH2 plus NH3.
Uses
Phenylhydrazine is used in the manufactureof dyes and pharmaceuticals; as a stabilizerfor explosive; as a reagent for aldehydes,ketones, and sugars in chemical analysis; andin organic synthesis.
Uses
An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.
General Description
Pale yellow crystals. Melting point 66°F. Becomes an oily liquid. Toxic by ingestion, inhalation and skin absorption. Flash point 192°F. Autoignition temperature 345°F. Soluble in alcohol.