4-Methoxybenzylamine (HCID 75452)

Names & identifiers

Preferred name: 4-Methoxybenzylamine
IUPAC: (4-methoxyphenyl)methanamine
English name: 4-Methoxybenzylamine
Molecular formula: C8H11NO
Molecular weight: 137.18

Names & synonyms

4-Methoxybenzylamine2393-23-9p-MethoxybenzylamineAnisylamineBenzenemethanamine, 4-methoxy-2M6QLM4NWENSC-9269DTXSID2062371RefChem:99632DTXCID1036967219-247-2(4-Methoxyphenyl)methanamine

Show more names

pmbnh24MBAPara Methoxy Benzyl AmineNSC 9269forSparfloxacine

1-(4-methoxyphenyl)methanamine4-Methoxy-benzylamine4-MethoxybenzenemethanamineBenzylamine, p-methoxy-MFCD00008122para-methoxybenzylamine(4-methoxyphenyl)methylaminep-methoxy benzylamine

Database identifiers

CAS: 2393-23-9
PubChem CID: 75452
DTXSID: DTXSID2062371
ChEMBL: CHEMBL12720
ChEBI: CHEBI:49837
UNII: 2M6QLM4NWE
Nikkaji: J101.237A

Properties

Computed structural properties

XLogP: 0.8
Topological polar surface area: 35.3 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 2
Heavy atoms: 10
Formal charge: 0
Complexity: 87

Experimental & physicochemical properties

Physical DescriptionColorless liquid with an amine-like odor; [Alfa Aesar MSDS]

Kovats Retention Index1232.6

Physicochemical properties

Melting point: -10 °C · -10°C
Boiling point: 236 · 236-237 °C (lit.)
Density: 1.05 g/mL · 1.05 g/mL at 25 °C (lit.)
vapor pressure: 26.67 Pa · 26.67Pa at 50℃
refractive index: 20 · n20/D 1.546(lit.)
Flash point: 230 °F · >230 °F
storage temp.: 2 · Keep in dark place,Inert atmosphere,2-8°C
solubility: soluble in Chloroform, Methanol
form: Liquid
pka: 9.3 · 9.30±0.10(Predicted)
Specific Gravity: 1.05 · 1.050
color: Clear colorless to slightly yellow
Water Solubility: It is highly soluble in water.
Sensitive: Air Sensitive
BRN: 508206 · 508206
LogP: 1.15 at · 1.15 at 25℃
CAS DataBase Reference: 2393 · 2393-23-9(CAS DataBase Reference)
FDA UNII: 2 M6QLM4NWE · 2M6QLM4NWE
NIST Chemistry Reference: 4 · Benzenemethanamine, 4-methoxy-(2393-23-9)
EPA Substance Registry System: 4 · Benzenemethanamine, 4-methoxy- (2393-23-9)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 280 · P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
Hazard Codes: C
Risk Statements: 34 · 34-37-22
Safety Statements: 26 · 26-36/37/39-45-27
RIDADR: 2735 · UN 2735 8/PG 2
WGK Germany: 3 · 3
Hazard Note: Corrosive
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29222900 · 29222900
REACH Registrations: Active

Safety & regulation

Hazard information

Regulatory Information4-Methoxybenzylamine: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; [Alfa Aesar MSDS] See Benzylamine.

Toxicology

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatory information

Regulatory Information4-Methoxybenzylamine: Does not have an individual approval but may be used under an appropriate group standard

Safety data

wgk: 3
tsca: TSCA listed
ridadr: UN 2735 8/PG 2
hs_code: 29222900
risk_code: 34-37-22
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
hazard_note: Corrosive
safety_code: 26-36/37/39-45-27
hazard_class: 8
packing_group: III
Hazard statements: H314
REACH Registrations: Active
Precautionary statements: P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationBenzenemethanamine, 4-methoxy-: ACTIVE

Applications

Uses4-Methoxybenzylamine is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. It is also used fine chemical intemediate.

Upstream & downstream products

Downstream products

4-Methoxybenzyl isocyanate 3-Chloro-4-methoxybenzylamine hydrochloride N-(4-Methoxybenzylidene)aniline N-(2-chloropyridin-3-yl)-2-{[(4-methoxyphenyl)methyl]amino}pyridine-3-carboxamide 2-Amino-N-(4-methoxybenzyl)benzamide N-(4-Methoxybenzyl)-4-(trifluoroMethyl)benzaMide, 97%2-Cyano-N-(4-methoxybenzyl)acetamide

Suppliers50 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

南京一化生物科技有限公司13429882898; 13429882898

爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]

Additional notes

DefinitionChEBI: 1-(4-methoxyphenyl)methanamine is an aralkylamino compound that is benzylamine substituted by a methoxy group at the para position. It is a primary amino compound, an aromatic ether and an aralkylamino compound.