Propylhexedrine

HCID 7558CAS 101-40-6

Substructure search Find similar structures

Basic information

Standard SMILES: CNC(C)CC1CCCCC1
InChIKey: JCRIVQIOJSSCQD-UHFFFAOYSA-N
Molecular formula: C10H21N
Average molar mass: 155.28 g/mol
Monoisotopic mass: 155.16739967

Names & identifiers

Preferred name: Propylhexedrine
IUPAC: 1-cyclohexyl-N-methylpropan-2-amine
English name: N,alpha-dimethylcyclohexaneethylamine
Molecular formula: C10H21N
Molecular weight: 155.28

Names & synonyms

PropylhexedrineBenzedrexHydromethamphetamineDristan Inhaler101-40-61-cyclohexyl-N-methylpropan-2-aminePropilhexedrinaPropylhexadrinePropylhexedrinumDL-propylhexedrine1-Cyclohexyl-2-(methylamino)propanePropilesedrina

Show more names

Chp-depotHexahydrodesoxyephedrineCyclohexaneethanamine, N,α-dimethyl-N,alpha-dimethylcyclohexaneethylamine(2-Cyclohexyl-1-methylethyl)methylamine

Methyl-(1-methyl-2-cyclohexylethyl)amineLQU92IU8LLNSC-32410(1-cyclohexylpropan-2-yl)(methyl)amine(+-)-N,alpha-DimethylcyclohexaneethylamineNSC32410Propylhexedrine dl-Cyclohexaneethanamine, N,alpha-dimethyl-

Database identifiers

CAS: 101-40-6、3595-11-7
PubChem CID: 7558
DTXSID: DTXSID1023526
ChEMBL: CHEMBL2105275
ChEBI: CHEBI:134783
UNII: LQU92IU8LL
EC Number: 202-939-3、222-741-0
Nikkaji: J21.261J

Properties

Computed structural properties

XLogP: 3.5
Topological polar surface area: 12 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 1
Rotatable bonds: 3
Heavy atoms: 11
Formal charge: 0
Complexity: 95

Experimental & physicochemical properties

Physical DescriptionSolid

Kovats Retention Index · 3 items

1170；1210；1185；1160；1176.2；1169

1179；1179；1161.7；1166.2；1157；1187；1193；1200

1410；1421；1431

Physicochemical properties

Boiling point: 209.13 °C · 209.13°C (estimate)
Density: 0.8501 · 0.8501
refractive index: 1.46 · 1.4600
pka: 10.78 · 10.78±0.10(Predicted)
FDA UNII: 92 IU8LL · LQU92IU8LL
Symbol(GHS): 6 · GHS06
Signal word: Danger
Hazard statements: 301 · H301
Precautionary statements: 264 · P264-P270-P301+P310-P321-P330-P405-P501
HazardClass: IRRITANT

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Hazard information

Regulatory InformationCyclohexaneethanamine, N,.alpha.-dimethyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesAcute Tox. 3 (100%)

Regulatory information

Safety data

Signal word: Danger
Symbol(GHS): GHS06
hazard_class: IRRITANT
Hazard statements: H301
Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501

Chemistry & industry

Pharmacology

Pharmacodynamics · 1 item

Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).

Mechanism of Action · 1 item

Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.

Cellular LocationsCytoplasm；Membrane