CAS 2627-35-2 Lauryl Phosphate (HCID 75816)

Overview

The CIR Expert Panel concluded the following 28 alkyl phosphates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating...Lauryl Phosphate...

Names & identifiers

Preferred name: Lauryl Phosphate
IUPAC: dodecyl dihydrogen phosphate
English name: Dodecyl dihydrogen phosphate
Molecular formula: C12H27O4P
Molecular weight: 266.31

Names & synonyms

Dodecyl dihydrogen phosphate2627-35-2Lauryl phosphateMonolauryl phosphateMonododecyl phosphateDihydrogen monolauryl phosphatePhosphoric acid, monododecyl esterLauryl dihydrogen phosphate0K08L8GE2HEINECS 220-095-4lauryl monophosphaten-dodecyl phosphate

Show more names

mono-n-DodecyLDODECYL PHOSPHATELauryl acid phosphatemono-lauryl phosphateChrome mist inhibitorDODECYLPHOSPHORIC ACIDMONO-DODECYL PHOSPHATEMONO-N-DODECYL PHOSPHATEDodecyldihydrogenphosphat

NSC 41919DODECYL ACID PHOSPHATEROMOL MAP HDODECANYL PHOSPHATENIKKOL PHOSTEN HLPNSC-41919PHOSPHANOL ML-200ETHFAC 102

Database identifiers

CAS: 2627-35-2
PubChem CID: 75816
DTXSID: DTXSID70880492
ChEMBL: CHEMBL187711
UNII: 0K08L8GE2H
EC Number: 220-095-4
Nikkaji: J192.141J

Properties

Computed structural properties

XLogP: 4
Topological polar surface area: 66.8 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 4
Rotatable bonds: 12
Heavy atoms: 17
Formal charge: 0
Complexity: 203

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Organophosphates, Other

Cosmetics · 2 items

Cosmetic ingredients (Lauryl Phosphate) -> CIR (Cosmetic Ingredient Review)

Emulsifying

Physical DescriptionWhite odorless crystals; [Alfa Aesar MSDS]

Physicochemical properties

Melting point: 39 · 39-45°C
Boiling point: 385.5 · 385.5±25.0 °C(Predicted)
Density: 1.056 · 1.056±0.06 g/cm3(Predicted)
pka: 1.95 · 1.95±0.10(Predicted)
form: White to off-white solid.
Water Solubility: Insoluble in water.
BRN: 1710518 · 1710518
InChI: 1S/C12H27O4P/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15/h2-12H2,1H3,(H2,13,14,15)
InChIKey: TVACALAUIQMRDF-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCOP(O)(O)=O
CAS DataBase Reference: 2627 · 2627-35-2(CAS DataBase Reference)
FDA UNII: 0 K08L8GE2H · 0K08L8GE2H
EPA Substance Registry System: Monolauryl phosphate (2627-35-2)
UNSPSC Code: 12352200 · 12352200
Symbol(GHS): 7 · GHS07
Signal word: Danger
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P280a-P304+P340-P305+P351+P338-P405-P501a
target organs: Respiratory system
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38-43-41-37/38
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 3261 · 3261
WGK Germany: 2 · WGK 2
TSCA: TSCA listed
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Irrit. 2Skin Sens. 1STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H314 (14.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 7 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

Chemical: Phosphoric acid, monododecyl ester

Phosphoric acid, monododecyl ester: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryPowder causes eye irritation; [Alfa Aesar MSDS] See Monooctyl phosphate.

Hazard Classes and CategoriesSkin Corr. 1B (14.3%)

Toxicology

Toxicity Summary · 2 items

The CIR Expert Panel concluded the following 28 alkyl phosphates are safe in the present practices of use and concentration in cosmetics when formulated to be non-irritating...Lauryl Phosphate...

Safe for use in cosmetics, with qualifications

Safety data

wgk: WGK 2
tsca: TSCA listed
ridadr: 3261
risk_code: 36/37/38-43-41-37/38
Signal word: Danger
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-36/37/39-45
Storage Class: 10 - Combustible liquids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Dam. 1Skin Irrit. 2Skin Sens. 1STOT SE 3
Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: Lauryl Phosphate

Use ClassificationCosmetics -> Emulsifying

General Manufacturing InformationPhosphoric acid, monododecyl ester: ACTIVE

Applications

Usesmono-n-Dodecyl phosphate is a lysophosphatidic acid (LPA) receptor ligand which serves as a specific agonist at EDG-4 (LPA2) (EC50=700 nM) and antagonist at EDG-7