hydroxylamine-O-sulfonic acid

HCID 76284
NotesReactions
Substructure searchFind similar structures

Basic information

CAS
2950-43-8
Standard SMILES
NOS(=O)(=O)O
InChIKey
DQPBABKTKYNPMH-UHFFFAOYSA-N
Molecular formula
H3NO4S
Average molar mass
113.1 g/mol
Monoisotopic mass
112.97827875

Names & identifiers

Preferred name
hydroxylamine-O-sulfonic acid
IUPAC
amino hydrogen sulfate
English name
Hydroxylamine-O-sulfonic acid
Molecular formula
H3NO4S
Molecular weight
113.09

Names & synonyms

Hydroxylamine-O-sulfonic acid2950-43-8Sulfamic acid N-oxideSulfoperamidic acidPermonosulfamic acidAmidosulfonic peracidHAOSAmidoperoxymonosulfuric acidAminomonopersulfuric acidHydroxylamine-O-sulphonic acidHydroxylaminesulfonic acidSulfuric acid, monoazanyl ester
Show more names
HOSAHOSHydroxylaMine-0-sulfonic acidAmino hydrogen sulphateo-hydroxylammoniumsulfonateTBX5
YM8MWJ7XSPDTXSID50883542RefChem:147204DTXCID001023065220-971-6amino hydrogen sulfate(aminooxy)sulfonic acidMFCD00011604

Database identifiers

CAS
2950-43-8
PubChem CID
76284
DTXSID
DTXSID50883542
UNII
YM8MWJ7XSP
EC Number
220-971-6
Nikkaji
J208.587I

Properties

Computed structural properties

XLogP
-3.9
Topological polar surface area
98 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
5
Rotatable bonds
1
Heavy atoms
6

Experimental & physicochemical properties

Physical DescriptionBeige hygroscopic powder; [Aldrich MSDS] White hygroscopic solid; [Alfa Aesar MSDS]

Physicochemical properties

Melting point
210 °C · 210 °C (dec.)(lit.)
Boiling point
39 °C · 39 °C(Press: 0.4 Torr)
Density
2.2 g/cm3 · 2.2 g/cm3 (20℃)
vapor pressure
0 · 0-53.329Pa at 25-39℃
storage temp.
2 · 2-8°C
solubility
675 g/l · 675g/l (slow decomposition)

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H302 (70.4%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H318 (67.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H400 (69.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H412 (66.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 162 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: Hydroxylamine-O-sulfonic acid

Status: Active Update: 10-06-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12342；Status: Cease Manufacture Update: 17-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/22751

Hydroxylamine-O-sulphonic acid: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 item

Causes burns; Inhalation can cause corrosive effects on the upper respiratory tract and lungs; [Aldrich MSDS] Causes burns; Inhalation can cause corrosive effects on the upper respiratory tract and lungs; May cause skin sensitization; [Alfa Aesar MSDS]

Hazard Classes and CategoriesAcute Tox. 4 (70.4%)；Skin Corr. 1B (100%)；Eye Dam. 1 (67.9%)；Aquatic Acute 1 (69.8%)；Aquatic Chronic 3 (66.7%)

Toxicology

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Regulatory information

Regulatory Information · 3 items

Chemical: Hydroxylamine-O-sulfonic acid

Status: Active Update: 10-06-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12342；Status: Cease Manufacture Update: 17-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/22751

Hydroxylamine-O-sulphonic acid: Does not have an individual approval but may be used under an appropriate group standard

Safety data

F
10-21
PPE
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
wgk
3
tsca
TSCA listed
rtecs
NC5427000
ridadr
UN 3260 8/PG 3

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationSulfuric acid, monoazanyl ester: ACTIVE
Applications · 3 items

UsesHydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.

UsesHydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid. HOSA may be used as an aminating reagent in the synthesis of:1-aminotetrazoles and 2-aminotetrazolesN-aminopiperidine (NAPP)1H,1′ H-2,2′-biimidazole-1,1′-diamine

General DescriptionHydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.

Upstream & downstream products

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
青岛君之道生物技术有限公司0532-87118899 13918827946 · [email protected]

Related reactions

389 records
New reaction record

Compound notes

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