CAS 3279-26-3 Phosphorodichloridous acid, methyl ester (HCID 76768)

Names & identifiers

Preferred name: Phosphorodichloridous acid, methyl ester
IUPAC: dichloro(methoxy)phosphane
English name: Methyl phosphorodichloridite
Molecular formula: CH3Cl2OP
Molecular weight: 132.91

Names & synonyms

Methyl phosphorodichloridite3279-26-3Phosphorodichloridous acid, methyl esterDTXSID20186451RefChem:158001DTXCID30108942221-915-3Methyl dichlorophosphitedichloro(methoxy)phosphaneDichloro Methyl PhosphiteMFCD00000524methyldichlorophosphite

Show more names

[Phosphitylating Agent]DICHLOROMETHOXY PHOSPHINEichloro(methoxy)phosphaneMethyl dichloridophosphiteMethyl dichlorophosphite,98%

Methyl phosphorodichloridoitemethyl dichlorophosphiniteCH3Cl2OPMethoxydichlorophosphineMethoxyphosphonous DichlorideO-Methyl PhosphorodichloriditeEINECS 221-915-3Phosphorodichloridous acid methyl ester

Database identifiers

CAS: 3279-26-3
PubChem CID: 76768
DTXSID: DTXSID20186451
EC Number: 221-915-3
Nikkaji: J208.737E

Properties

Computed structural properties

XLogP: 1.6
Topological polar surface area: 9.2 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 5
Formal charge: 0
Complexity: 23

Physicochemical properties

Melting point: -91 °C · -91 °C (lit.)
Boiling point: 93 · 93-95 °C (lit.)
Density: 1.376 g/mL · 1.376 g/mL at 20 °C (lit.)
refractive index: 20 · n20/D 1.474(lit.)
Flash point: 104 °F · 104 °F
storage temp.: 20 °C · −20°C
solubility: soluble in Chloroform, Dichloromethane, Ethyl Acetate
form: liquid
color: Colorless to Almost colorless
Water Solubility: Reacts with water. Soluble in chloroform, dichloromethane and ethyl acetate.
Sensitive: Moisture Sensitive
BRN: 1697452 · 1697452
Stability: Flammable.
InChI: 1S/CH3Cl2OP/c1-4-5(2)3/h1H3
InChIKey: HCSDJECSMANTCX-UHFFFAOYSA-N
SMILES: COP(Cl)Cl
CAS DataBase Reference: 3279 · 3279-26-3(CAS DataBase Reference)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 2 · GHS02,GHS05,GHS07
Signal word: Danger
Hazard statements: 226 · H226-H314-H335
Precautionary statements: 210 · P210-P233-P240-P280-P303+P361+P353-P305+P351+P338
target organs: Respiratory system
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C
Risk Statements: 10 · 10-14-34-37
Safety Statements: 26 · 26-36/37/39-45
RIDADR: 2920 · UN 2920 8/PG 2
WGK Germany: 3 · 3
F: 10 · 10-13-23
HazardClass: 8 · 8
PackingGroup: II
HS Code: 29209090 · 29209090
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 3 Skin · Flam. Liq. 3Skin Corr. 1BSTOT SE 3

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]；H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H335 (88.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationPhosphorodichloridous acid, methyl ester: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (100%)；Skin Corr. 1B (100%)；STOT SE 3 (88.6%)

Regulatory information

Regulatory InformationPhosphorodichloridous acid, methyl ester: Does not have an individual approval but may be used under an appropriate group standard

Safety data

F: 10-13-23
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 3
ridadr: UN 2920 8/PG 2
hs_code: 29209090
risk_code: 10-14-34-37
Signal word: Danger
Symbol(GHS): GHS02,GHS05,GHS07
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
Storage Class: 3 - Flammable liquids
packing_group: II
target organs: Respiratory system
Hazard statements: H226-H314-H335
Hazard Classifications: Flam. Liq. 3Skin Corr. 1BSTOT SE 3
Precautionary statements: P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

Chemistry & industry

Applications · 2 items

UsesEmployed in the synthesis of phosphorodichloridothioates1 and oxazaphosphorinanes2 from sulfenyl chlorides and a chiral amino alcohol, respectively.

UsesMethyl dichlorophosphite has been employed in the preparation of:phosphonamidate- and phosphonate-linked phosphonopeptides2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcoholdeoxyoligonucleotides on a polymer supportcis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinanephosphorodichloridothioates oxazaphosphorinanes