N-methylhydroxylamine hydrochloride
Basic information
- CAS
4229-44-1- Standard SMILES
CNO.Cl- InChIKey
RGZRSLKIOCHTSI-UHFFFAOYSA-N- Molecular formula
- CH5NO.ClH
- Average molar mass
- 83.52 g/mol
- Monoisotopic mass
- 83.01379149
Names & identifiers
- Preferred name
- N-methylhydroxylamine hydrochloride
- IUPAC
- N-methylhydroxylamine;hydrochloride
- English name
- N-Methylhydroxylamine hydrochloride
- Molecular formula
- CH6ClNO
- Molecular weight
- 83.52
Names & synonyms
N-Methylhydroxylamine hydrochloride4229-44-1Methylhydroxylammonium chlorideMethylhydroxylamine hydrochlorideN-Methylhydroxylammonium chlorideMethanamine, N-hydroxy-, hydrochlorideMGW04SJ1LZMethanamine, N-hydroxy-, hydrochloride (1:1)Hydroxylamine, N-methyl-, hydrochlorideNSC-48213DTXSID5063368RefChem:163840
Show more names
42229-44-1N-MethylhydroxylaminN-METHYLHYDROXYAMINEHCLMethyl hydroxylamine .HCLN-Methylhydroxyaminehydrochloriden-hydroxy-methanaminhydrochlorideN-Hydroxymethanamine hydrochloride
DTXCID6040080224-181-2N-METHYLHYDROXYLAMINE HCLMFCD00012597UNII-MGW04SJ1LZEINECS 224-181-2NSC 48213AI3-52591
Database identifiers
- CAS
4229-44-1- PubChem CID
- 77906
- DTXSID
DTXSID5063368- UNII
- MGW04SJ1LZ
- EC Number
- 224-181-2
Properties
Computed structural properties
- Topological polar surface area
- 32.3 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Formal charge
- 0
- Complexity
- 4.8
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Hydroxylamines
Physical DescriptionBeige hygroscopic crystalline solid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 86 · 86-88 °C(lit.)
- Density
- 1.36 g/cm3 · 1.36 g/cm3
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 2 O: · H2O: 0.1 g/mL, clear, very faintly yellow
- form
- solid
- color
- white
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3541409 · 3541409
- InChI
- InChI=1S/CH5NO.ClH/c1-2-3;/h2-3H,1H3;1H
- InChIKey
- RGZRSLKIOCHTSI-UHFFFAOYSA-N
- SMILES
- N(O)C.Cl
- CAS DataBase Reference
- 4229 · 4229-44-1(CAS DataBase Reference)
- FDA UNII
- 4 SJ1LZ · MGW04SJ1LZ
- EPA Substance Registry System
- Methanamine, N-hydroxy-, hydrochloride (4229-44-1)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 302 · P302+P352-P305+P351+P338
- target organs
- Respiratory system
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26-36-24/25
- RIDADR
- 1759 · 1759
- WGK Germany
- 3 · 3
- F
- 3 · 3-10
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- III
- HS Code
- 29280090 · 29280090
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 47 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Methanamine, N-hydroxy-, hydrochloride
Methanamine, N-hydroxy-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals not considered for in depth evaluation - Not commercially active in Australia
Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- F
- 3-10
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- 1759
- hs_code
- 29280090
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36-24/25
- hazard_class
- 8
- Storage Class
- 11 - Combustible Solids
- packing_group
- III
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P302+P352-P305+P351+P338
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationMethanamine, N-hydroxy-, hydrochloride (1:1): INACTIVE
Applications
UsesN-Methylhydroxylamine hydrochloride is used as an inorganic catalyst used in the transamidation of primary amides with amines. It is employed in constructing hydroxamates, important functional groups for the complexation of iron.
Preparation methods
PreparationN-methylhydroxylamine hydrochloride (N-MHA) was synthesized by a high pressure catalytic hydrogenation method using noble metal Pd/C and Pt-Rh/C as the catalyst. During the synthesis process, the catalyst was easily poisoned and the products would be deeply reduced to methylamine. Therefore, the purity of N-MHA is low and the cost is high. An industrial electrolytic cell was designed for the electrochemical synthesis of N-methylhydroxylamine hydrochloride (N-MHA). Copper was used as the cathode, graphite as the anode, and a cation membrane as the separator. The results show that N-MHA with a high purity of 99% can be electrosynthesized directly from nitromethane in HCl solution.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
216 records
Compound notes
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