Basic information
- CAS
4253-34-3- Standard SMILES
CC(=O)O[Si](C)(OC(C)=O)OC(C)=O- InChIKey
TVJPBVNWVPUZBM-UHFFFAOYSA-N- Molecular formula
- C7H12O6Si
- Average molar mass
- 220.25 g/mol
- Monoisotopic mass
- 220.04031463
Names & identifiers
- Preferred name
- Methyltriacetoxysilane
- IUPAC
- [diacetyloxy(methyl)silyl] acetate
- English name
- Methyltriacetoxysilane
- Molecular formula
- C7H12O6Si
- Molecular weight
- 220.25
Names & synonyms
Methyltriacetoxysilane4253-34-3Methylsilanetriyl triacetateSilanetriol, methyl-, triacetateEINECS 224-221-9Silanetriol, 1-methyl-, 1,1,1-triacetatetriacetoxy(methylsilane)NSC 139845DTXSID0027565BRN 1788668EC 224-221-94-04-00-04208 (Beilstein Handbook Reference)
Show more names
MTASKH-310Triacetoxy(methyl)siapk1(silanederivative)LABOTEST-BB LT01406986Modified methyltriacetoxysilancek10ssilanetriol,Triacetoxy(methyL
DTXCID507565CM8980Silane, methyltriacetoxyRefChem:158342Silanetriol, methyl, triacetateSilanetriol, 1methyl, 1,1,1triacetate224-221-9TVJPBVNWVPUZBM-UHFFFAOYSA-N
Database identifiers
- CAS
4253-34-3- PubChem CID
- 77929
- DTXSID
DTXSID0027565- ChEMBL
CHEMBL3184776- UNII
- W4FX3GZ7AB
- EC Number
- 224-221-9
- Nikkaji
- J54.327F
Properties
Computed structural properties
- Topological polar surface area
- 78.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 6
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 220
Experimental & physicochemical properties
Chemical ClassesMetals -> Metalloid Compounds (Silicon)
SpringerMaterials PropertiesSound absorption
Density1.175 @ 20°C
Melting Point40.5 °C
Vapor Pressure0.2 [mmHg]
Physical Description
Liquid; Other Solid; Liquid
Solid; [Alfa Aesar MSDS]
Physicochemical properties
- Melting point
- 40 · 40-45 °C(lit.)
- Boiling point
- 94 · 94-95 °C9 mm Hg(lit.)
- Density
- 1.2 g/mL · 1.20 g/mL at 20 °C(lit.)
- vapor pressure
- 0.053 · 0.053-26Pa at 20-25℃
- refractive index
- 1.52 · 1.52-1.522
- Flash point
- 185 °F · 185 °F
- solubility
- soluble in Methanol
- form
- solid
- Specific Gravity
- 1.175 · 1.175
- color
- White or Colorless to Almost white or Almost colorless
- Odor
- Acrid odor
- Water Solubility
- 1000 g/L · 1000g/L at 20℃
- Hydrolytic Sensitivity
- 7 · 7: reacts slowly with moisture/water
- Sensitive
- Moisture Sensitive
- BRN
- 1788668 · 1788668
- InChI
- 1S/C7H12O6Si/c1-5(8)11-14(4,12-6(2)9)13-7(3)10/h1-4H3
- InChIKey
- TVJPBVNWVPUZBM-UHFFFAOYSA-N
- SMILES
- CC(=O)O[Si](C)(OC(C)=O)OC(C)=O
- LogP
- -2.4 at · -2.4 at 20℃
- CAS DataBase Reference
- 4253 · 4253-34-3(CAS DataBase Reference)
- FDA UNII
- 4 FX3GZ7AB · W4FX3GZ7AB
- NIST Chemistry Reference
- Methyltriacetoxysilane(4253-34-3)
- EPA Substance Registry System
- 1 · Silanetriol, 1-methyl-, 1,1,1-triacetate (4253-34-3)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 5 · GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 302 · H302-H314
- Precautionary statements
- 260 · P260-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26-36
- RIDADR
- 1759 · UN1759
- WGK Germany
- 2 · 2
- RTECS
- 4500000 · VV4500000
- F
- 9 · 9-21
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- III
- HS Code
- 29319090 · 29319090
- Storage Class
- 8 A · 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- 4 OralSkin · Acute Tox. 4 OralSkin Corr. 1B
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.9% (5 of 561) of reports.
Danger
H302 (73.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 561 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
Hazard information
Regulatory Information
Chemical: Silanetriol, methyl-, triacetate
Silanetriol, 1-methyl-, 1,1,1-triacetate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silanetriol, 1-methyl-, 1,1,1-triacetate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 04-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14400
Silanetriol, methyl-, triacetate, >5% in a non hazardous diluent: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards Summary
Causes severe irritation and burns to skin and eyes in rabbits; Rapidly hydrolyzed by moisture/water forming acetic acid and the corresponding trisilanols (observed toxicity attributed to acetic acid); [OECD SIDS: Methyltriacetoxysilane - 2005] An irritant; Harmful by ingestion; [Alfa Aesar MSDS] See Acetic acid. See Ethyltriacetoxysilane.
Hazard Classes and Categories
Acute Tox. 4 (73.6%)
Acute toxicity (Oral) - Category 4
Safety & protection
Protective Action Criteria (PAC)
6.2 [mg/m3]
68 [mg/m3]
410 [mg/m3]
Toxicology
Adverse EffectsDermatotoxin - Skin burns.
Safety data
- F
- 9-21
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- VV4500000
- ridadr
- UN1759
- hs_code
- 29319090
- risk_code
- 36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS07
- hazard_code
- Xi
- safety_code
- 26-36
- hazard_class
- 8
- Storage Class
- 8A - Combustible corrosive hazardous materials
- packing_group
- III
- Hazard statements
- H302-H314
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralSkin Corr. 1B
- Precautionary statements
- P260-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338
Chemistry & industry
Uses & manufacturing
Uses
Used as a cross-linker for silicone sealants and adhesives (completely reacts during curing); [OECD SIDS: Methyltriacetoxysilane - 2005]
Working with Glues and Adhesives [Category: Other]
U.S. Production2023: 1,000,000 - <5,000,000 lb
Consumer UsesWaterproofing agent
Industry UsesSealant (barrier)
Household ProductsInformation on 47 consumer products that contain Methyltriacetoxysilane in the following categories is provided:
General Manufacturing Information
Adhesive Manufacturing
Silanetriol, 1-methyl-, 1,1,1-triacetate: ACTIVE
Applications
UsesMethyltriacetoxysilane is used as a silane coupling agent.
Preparation methods
PreparationCurrently, in industry, methyltrichlorosilane and acetic anhydride are commonly used as raw materials for acylation reactions to synthesize methyltriacetoxysilane products. The content can reach over 95%, and the total chlorine content is ≤100ppm. The reaction formula is as follows: CH3SiCl3 + 3C4H6O3 → (CH3CO2)3SiCH3 + 3C2H3ClO. The production process is as follows: Using methyltrichlorosilane and acetic anhydride as raw materials, the materials are added to the synthesis reactor in a certain proportion for the acylation reaction. The temperature is first raised to 80℃ for atmospheric pressure reflux reaction, and acetyl chloride is collected while refluxing at 80~95℃ until the flow is stopped. The semi-finished methyltriacetoxysilane in the synthesis reactor is transferred to a crude synthesis tank. The semi-finished product is then pumped to an acetyl chloride vacuum thin-film evaporator, where the feeding temperature is controlled at 100℃ to distill off acetic anhydride and acetyl chloride. The material is then pumped to an acetic anhydride vacuum thin-film evaporator, where the feeding temperature is controlled at 105-115℃ to obtain the finished methyltriacetoxysilane. Material containing a large amount of acetic anhydride is extracted from both vacuum thin-film evaporators and returned to the synthesis reactor. The finished methyltriacetoxysilane is then decolorized in a decolorization reactor using activated carbon at 70℃. After decolorization, the material is filtered through a candle filter into a modification reactor to obtain pure methyltriacetoxysilane.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
南通润丰石油化工有限公司66017690 19952660367 · [email protected]
上海比阳实业有限公司+86-21-52699951; +8613917686115 · [email protected]
武汉欣扬瑞和化学科技有限公司153-07155313 15307155313 · [email protected]
温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]
上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]
河北创海生物科技有限公司+86-86-13131129325 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
武汉卡诺斯科技有限公司027-83238443 15327105076 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
山东洛克化工有限公司17653113209 13065062079 · [email protected]
上海比阳实业有限公司+86-15021878111 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
Xiamen AmoyChem Co., Ltd+86-86-5926051114 · [email protected]
艾科试剂4008-755-333 18080918076 · [email protected]
武汉欣扬瑞和化学科技有限公司027-83855316 18171155316 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.+86-0532-8699-9256 +86-18518128472 · [email protected]
上海遐瑞医药科技有限公司+86 21 61551611
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
上海裕兰生物科技有限公司021-57171705 13817537615 · [email protected]
上海湄水化工科技有限公司021-60549325 18616193163
上海将来实业股份有限公司021-61552785 · [email protected]
安徽科迪达化工有限公司0554-2106669 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
上海探圭新材料科技有限公司18516111942 · [email protected]
上海石洋化工有限公司021-56795766 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
湖北巨胜科技有限公司027-59599241 18871490274 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
桦特昇生物科技（武汉）有限公司027-59207879 1972026995 18140587686 · [email protected]
九鼎化学（上海）科技有限公司4009209199 · [email protected]
Henan Alfa Chemical Co., Ltd+8618339805032 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
山东智尚新材料有限公司+8617653113209 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
上海石洋化工有限公司+86-021-56795779 +86-13651600618 · [email protected]
北京华威锐科化工科技有限公司89508211 18501085097 · [email protected]
Related reactions
7 records
Compound notes
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