L-(+)-tartaric acid; rivastigmine
Basic information
- CAS
129101-54-8- Standard SMILES
CCN(C)C(=O)Oc1cccc([C@H](C)N(C)C)c1.O=C(O)[C@@H](O)[C@H](O)C(=O)O- InChIKey
GWHQHAUAXRMMOT-RWALOXMOSA-N- Molecular formula
- C18H28N2O8
- Average molar mass
- 400.4 g/mol
- Monoisotopic mass
- 400.18456586
Names & identifiers
- Preferred name
- L-(+)-tartaric acid; rivastigmine
- IUPAC
- (2S,3S)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
- English name
- Rivastigmine tartrate
- Molecular formula
- C18H28N2O8
- Molecular weight
- 400.42
Names & synonyms
CAS-129101-54-8CHEMBL3187096L-(+)-tartaric acid; rivastigmineTox21_112528AKOS025149495Tox21_112528_1NCGC00167531-02NCGC00167531-14ST110910(2S,3S)-2,3-Dihydroxybutanedioic acid--3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate (1/1)RivastigMine BitartrateCS-118
Show more names
ENA-713SDZ-ENA 713Rivastigmine tartrateRivastigimine tartrateS-Rivastigmine tartraterivastigMine ditartrateRivastigMine L-TartrateRivastigmine-d6 tartarate
Database identifiers
- CAS
129101-54-8- PubChem CID
- 77990
- DTXSID
DTXSID8047840- ChEMBL
CHEMBL3187096
Properties
Computed structural properties
- Topological polar surface area
- 148 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 8
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 402
Physicochemical properties
- Melting point
- 123 · 123-1250C
- alpha
- 20 · D20 +4.7° (c = 5 in ethanol)
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
- optical activity
- 3.5 ° · 3.50°(C=0.01g/mL, MEOH, 589nm)
- Water Solubility
- 2 O: · H2O: 15mg/mL, clear
- InChI
- InChI=1/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/s3
- InChIKey
- GWHQHAUAXRMMOT-AAUFCPPMNA-N
- SMILES
- C1(=CC=CC([C@H](C)N(C)C)=C1)OC(=O)N(C)CC.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:5,18,23,r|
- CAS DataBase Reference
- 129101 · 129101-54-8(CAS DataBase Reference)
- FDA UNII
- 9 IY2357JPE · 9IY2357JPE
- NCI Drug Dictionary
- rivastigmine tartrate
- UNSPSC Code
- 41116107 · 41116107
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- FA9550000
- ridadr
- UN 2811 6.1 / PGII
- hs_code
- 29242990
- Signal word
- Danger
- Symbol(GHS)
- GHS06,GHS09
- hazard_class
- 6.1
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- packing_group
- III
- Hazard statements
- H300-H411
- Hazard Classifications
- Acute Tox. 2 OralAquatic Chronic 2
- Precautionary statements
- P264-P270-P273-P301+P310-P391-P405
Chemistry & industry
Applications
UsesRivastigmine Tartrate, a cholinesterase inhibitor with IC50 of 5.5 μM, ues as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
UsesNootropic & Alzheimer’s treatment
UsesA brain selective acetylcholinesterase inhibitor. Nootropic.
General DescriptionPharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Additional notes
DefinitionChEBI: A tartrate salt obtained by reaction of rivastigmine with one equivalent of (R,R)-tartaric acid. A reversible cholinesterase inhibitor.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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