1,2-Epoxybutane

Fire Extinguishing Agents Not to Be Used: Water may be ineffective.

Use foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Artificial respiration may be needed. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Use water spray to cool unopened containers.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carfully resealed and kept upright to prevent leakage.

Chemical stability: stable under recommended storage conditions.

Store in a cool, dry, well-ventilated location. Store away from heat, oxidizing materials, and sunlight.

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources or ifnition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas...

Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up: contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations...

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": HEPA (high-efficiency particulate arrestor) filters ... can be disposed of by incineration. For spent charcoal filters, the adsorbed material can be stripped off at high temp & carcinogenic wastes generated by this treatment conducted to & burned in an incinerator. ... LIQUID WASTE: ... Disposal should be carried out by incineration at temp that ... ensure complete combustion. SOLID WASTE: Carcasses of lab animals, cage litter & misc solid wastes ... should be disposed of by incineration at temp high enough to ensure destruction of chem carcinogens or their metabolites. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for 1-BUTENE OXIDE (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1-butene oxide is expected to have very high mobility in soil(SRC). Volatilization of 1-butene oxide from moist soil surfaces is expected to be an important fate process(SRC), given an estimated Henry's Law constant of 1.70X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 170 mm Hg(3), and its water solubility, 95,500 mg/L(4). 1-Butene oxide is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. A 100% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC). Results of various biodegradation screening tests suggest that 1-butene oxide is readily biodegradable(3). 1-Butene oxide has an aqueous hydrolysis half-life of about 6.5 days at pH 7 and 25 °C(3,4); therefore, hydrolysis may be an important fate process in moist soils(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that 1-butene oxide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a estimated Henry's Law constant of 1.7X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 170 mm Hg(4), and its water solubility, 95,500 mg/L(4). Using this Henry's Law constant and an estimation method(2), volatilization half-lives for a model river and model lake are 6.9 hours and 4.7 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.68(3) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 100% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in water(SRC). Results of various biodegradation screening tests suggest that 1-butene oxide is readily biodegradable(3). The epoxides (such as butene oxide) degrade in water by hydrolysis and related ionic reactions to glycols(7); hydrolysis of 1-butene oxide yields 1,2-butene glycol (also known as 1,2-butanediol)(7). 1-Butene oxide has an aqueous hydrolysis half-life of about 6.5 days at pH 7 and 25 °C(3,4). In seawater, the hydrolysis rate of the similar 1-propene oxide is accelerated by at least 30% due to chloride ion reaction(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-butene oxide, which has a vapor pressure of 170 mm Hg at 24 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase 1-butene oxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is 8.4 days(SRC), calculated from its rate constant of 1.91X10-12 cu cm/molecule-sec at 25 °C(3). Epoxides, such as 1-butene oxide, may be formed in the ambient atmosphere via reaction of alkenes with various atmospheric oxidants(4). 1-Butene oxide may react with tropospheric aerosols and water to yield 1,2-butanediol through hydrolysis, especially under acidic conditions(4).

IDENTIFICATION AND USE: 1-Butene oxide is a colorless liquid with a pungent, disagreeable, sweetish odor, somewhat like butyric acid. It is used as an intermediate, for various polymers, a stabilizer for chlorinated solvents, and a corrosion inhibitor. 1-Butene oxide is also used as an acid scavenger for chlorine-containing materials such as trichloroethylene and to react with ammonia to produce alkanolamines. HUMAN EXPOSURE AND TOXICITY: 1-Butene oxide is possibly carcinogenic to humans (Group 2B). ANIMAL STUDIES: 1-Butene oxide was irritating to the eyes. Irritating effects to the skin were severe (corrosion) if evaporation was minimized due to occlusive application, but there was no effect by semi-occlusive application. It was not sensitizing in a guinea pig maximization test. In 90-day inhalation studies with rats and mice 1-butene oxide mainly caused nasal lesions. Systemic effects occurred at higher concentrations (rat 2400 mg/cu m: decreased mean body weight gain; mice 2400 mg/cu m: e.g. renal tubular necrosis). There is clear evidence for 1-butene oxide being a locally acting carcinogen in male rats (inhalation of 600 mg/cu m caused no tumors and 1,200 mg/cu m caused neoplasms of the nasal cavity and the lung of male rats) and there is equivocal evidence for a carcinogenic activity in female rats. There was no evidence for carcinogenic activity in male or female mice. 1-Butene oxide was genotoxic in vitro. However, it did not cause chromosomal aberrations in bone marrow or dominant-lethal mutations in germ cells of rats. With respect to reproductive toxicity the 90 day studies with rat and mice did not reveal adverse effects on the reproductive organs up to 2400 mg/kg body weight. Additionally, the lack of an effect from pre-gestational exposure in the developmental toxicity study and a negative dominant-lethal test may indicate that 1,2-epoxybutane does not reach male and female germ cells in effective concentrations. No developmental toxicity or teratogenicity was detected in rats after inhalation of up to 3,000 mg/cu m throughout gestation.

Cough. Sore throat. Laboured breathing. Headache. Drowsiness.

Redness.

Redness. Pain.

Abdominal pain. See Inhalation.

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=106-88-7]

1,2-Epoxybutane (EBU)

Respiratory

2 x 10 ^-2 mg/m^3

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-butene oxide can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-butene oxide is expected to have very high mobility in soil.

Dermal sensitization was evaluated in 10 male Hartley guinea pigs receiving dermal applications of 1,2-epoxybutane (purity not reported). The test material was applied as an occluded dose 4 times at 48 hour intervals over a 7 day treatment period; 0.2 ml of Freunds Adjuvant was injected intradermally adjacent to the treatment site at the time of the third application. Following a 2 week rest period, animals were challenged with an unspecified amount of test material to their shaved flanks. The investigators observed no sensitization reaction in any of the 10 animals when compared to controls.[Dow Chemical; 1,2-Butylene oxide: Skin sensitization potential in the guinea pig. (1984), EPA Document No. 40- 8475031, Fiche No. OTS0507304]

Subchronic inhalation toxicity was evaluated in a range finding study using 1,2 epoxybutane (purity not reported) to determine the exposure concentrations for chronic study. Groups of 20 Fischer-344 rats (10 male, 10 female) and 20 B6C3F1 mice (10 male, 10 female) were exposed to 0,50,100,200,400 or 800 ppm 1,2 epoxybutane for 13 weeks. The number of hours/day and days/week of exposure were not reported. The investigators observed severe inflammation of the nasal cavity, hemorrhage of the tracheobronchial lymph nodes, and statistically significantly decreased body weight gain in rats exposed at 800 ppm; the incidence and severity of lesions in rats exposed at other levels were not considered to be different from controls. Observations in mice exposed to 800 ppm included inflammation of the nasal cavity, red discoloration of the lungs, paleness of the spleen, distension of the G.I. tract, thymic necrosis, thymic atrophy, splenic atrophy, splenic necrosis, along with renal tubular necrosis and inflammation. At 200 and 400 ppm mice exhibited a reduction in the number of cell layers in the olfactory epithelium and an increase in amount of serous fluid, especially in the recesses of the turbinate area; but no effects on the thymus, spleen or kidneys.

The effect of butylene oxide was examined in the Drosophila sex-linked recessive lethal assay. Male flies were exposed to 1000 ppm test article for 7 hours and then mated. Butylene oxide did not substantially increase the incidence of lethals in the F1, F2 or F3 generations compared to controls. A survival rate of 70% was observed after 7 hours of exposure indicating that butylene oxide was being tested at toxic levels.

The effect of butylene oxide (dissolved in DMSO) was examined in the DNA repair assay with and without metabolic activation provided by Aroclor-induced rat liver S9 fraction. Human embryonic intestinal cells were exposed for 3 hours to concentrations of test article ranging from 11 to 525 ug/mL in activated assays, and from 57 to 7300 ug/mL in nonactivated assays. Butylene oxide did not induce an increase in the number of grain counts at any concentration. Toxicity to cells was observed at concentrations greater than 525 ug/ml in assays with activation, while toxicity in assays without activation was not reported.

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Oxirane, ethyl- is included on this list. Effective date: 10/04/82; Sunset date: 10/04/92.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. 1-Butene oxide is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).