Propylamine

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:

Use powder, alcohol-resistant foam, water in large amounts, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention.

Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.

Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention.

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

Call a physician.

General First Aid:

Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams of water may be ineffective and spread material.

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Outside or detached storage is prefered. Avoid oxidizing material, acids, and sources of halogen. Store in a cool, dry, well-ventilated location.

Keep Tightly Closed.

Overspread/spill with/ sufficient sodium bisulfate and sprinkle /with/ water. /Ethylamine/

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors.

[40 CFR 240-280, 300-306, 702-799 (7/1/2006)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U194, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U194, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

EC50; Species: Anabaena subcylindrica (Blue-green algae, axenic, 1-3x 10+7 cells/mL); Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 0.012 ug/cell for < or = 3 hr; Effect: decreased nitrogen fixation

EC50; Species: Anabaena subcylindrica (Blue-green algae, axenic, 1-3x 10+7 cells/mL); Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 1.8x10-8 ug/cell for < or = 3 hr; Effect: photosynthesis, oxygen production

EC50; Species: Chlorella ellipsoidea (Green algae, axenic); Conditions: freshwater, static, 25 °C, pH 7.2; Concentration: 0.4x10-8 ug/cell for 90 min; Effect: photosynthesis, oxygen production

EC50; Species: Daphnia magna (Water flea, Lake Langedam strain, age <24 hr); Conditions: freshwater, static, 20 °C, pH 7.8-8.0, hardness 250 mg/L CaCO3, dissolved oxygen 94-99%; Concentration: 100 mg/L for 24 hr; Effect: intoxication, immobilization

For more Ecotoxicity Values (Complete) data for PROPYLAMINE (7 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a log Kow of 0.48(2) and a regression-derived equation(3), indicates that propylamine is expected to have very high mobility in soil(SRC). The pKa of propylamine is 10.71(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of propylamine from moist soil surfaces is not expected to be an important fate process given its cationic state(SRC). Propylamine is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 310 mm Hg(6). Biodegradation of propylamine is expected to occur(7-9); a 102% theoretical BOD was measured after 13 days using a non-activated sludge inoculum(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 43(SRC), determined from a log Kow of 0.48(2) and a regression-derived equation(3), indicates that propylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.71(4) indicates propylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation of propylamine is expected to occur(8-10); a 102% of theoretical BOD was measured after 13 days using a non-activated sludge inoculum(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), propylamine, which has a vapor pressure of 310 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase propylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 3.3X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Propylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The following naturally occuring concns of propylamine (in mg/kg) were detected in various food products from W Germany: fresh rutabaga, 5.0; paprika, 2.3; paprika brine, 10.6; cucumber, 0.1-7.5; pepperoni, 1.4; pickled onions, 1.8; celery, 2.7; cheese, 2-8.7; brown bread, 1.6; freeze-dried coffee and coffee extract, trace-0.5(1). Propylamine has been qualitatively detected in wine, beer, rice, barley, malt, and corn(2,3).

... The presence of volatile aliphatic amines ... in human breast milk and amniotic fluid /was measured/ to assess their role in neonatal hypergastrinemia. These volatile nitrogenous amino acid metabolites have been previously demonstrated to stimulate gastrin release in in vivo and in vitro laboratory preparations. ... The present study ... demonstrated that these gastrin-stimulatory volatile amines were present in significant concentrations in breast milk during the first several weeks after parturition and in amniotic fluid. The individual amines that were identified in both human milk and amniotic fluid samples were methylamine, dimethylamine, ethylamine, trimethylamine, propylamine, isobutylamine, and butylamine. This study provides indirect evidence to support the possibility that the hypergastrinemia measured in the fetus/neonate during the period immediately before and after birth may be attributable, in part, to the ingestion of fluid containing high concentrations of gastrin-stimulating amines.

/OTHER TERRESTRIAL SPECIES/ ... This research compared the toxicity and inhibition caused by three aliphatic amines (n-propylamine, ethylmethylamine, and trimethylamine) and their chlorinated derivatives. ... Acute toxicity assays were conducted by using a Microtox system with Phosphobacterium phosphoreum (also known as Vibrio fischeri) for the aliphatic amine compounds and their corresponding chlorinated derivatives, as identified by membrane introduction mass spectrometry (MIMS). Inhibition tests were conducted by using the oxygen utilization rate test with an enhanced nitrifier culture. ... Trimethylamine and n-propylamine caused greater inhibition to nitrifiers than did ethylmethylamine under similar concentrations. Nitrifier inhibition from these amines increased after chlorination.

Propylamine has been identified in rice, corn, and barley(1) and occurs naturally in various species of marine algae(2). Latakia tobacco leaf has been found to contain propylamine(3). Propylamine has been detected in medicinal plant root samples collected from Nigeria, Africa, concn not specified(4).

Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed.

Redness. Pain. Serious skin burns.

Watering of the eyes. Redness. Pain. Blurred vision. Severe burns. Loss of vision.

Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain. Vomiting. Diarrhoea. Shock or collapse.

A propylamine concn of 400 ppm was detected in a 1980 waste sample which was discharged into the ocean 74 km north of Arebico, Puerto Rico from a pharmaceutical manufacturer(1). In a laboratory study, propylamine was detected in the automobile exhaust of two gasoline fueled vehicles, concn not specified(2). An estimated 600 tons of propylamine are annually released in industrial effluents from industrial manufacturers (rubber chemicals, dyestuffs, pharmaceuticals, agricultural chemicals, corrosion inhibitors, textile and leather finishing resins) and users of the compound(3).

The Koc of propylamine is estimated as 43(SRC), using a log Kow of 0.48(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that propylamine is expected to have very high mobility in soil. The pKa of propylamine is 10.71(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

U194; As stipulated in 40 CFR 261.33, when 1-propanamine, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 1-Propanamine is included on this list.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Propylamine is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).